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HCV genotypes in Swedish blood donors as correlated to epidemiology, liver disease and hepatitis C virus antibody profile

Shev, S; Widell, Anders LU ; Foberg, U; Fryden, A; Hermodsson, S; Lindh, G; Lindholm, A; Månsson, Siv; Weiland, O and Norkrans, G (1995) In Infection 23(5). p.253-257
Abstract (Swedish)
Abstract in German

62 anti-HCV und HCV-RNA-positive schwedische Blutspender (44 Männer, 18 Frauen, Alter im Median 34 Jahre) wurden untersucht. Die HCV-Genotypen wurden in Korrelation gesetzt zu parenteralen Risikofaktoren, Lebermorphologie, Serum-Alanin-Aminotransferase (ALAT)-Spiegeln und HCV-Antikörperprofil. 40% der Spender waren mit dem HCV-Genotyp 1a infiziert, 10% mit 1b, 21% mit 2b und 29% mit 3a. Bei Spendern mit Genotyp 3a bestand häufiger eine Vorgeschichte von intravenösem Drogenabusus als bei den mit Genotyp 1a Infizierten (p=0,024). Bluttransfusionen waren bei Genotyp 2b häufiger vorausgegangen als bei Typ 3a (p=0,012). Bei 38% der mit Genotyp 2b aber nur bei 8% der mit Genotyp 1a infizierten Spender fand sich... (More)
Abstract in German

62 anti-HCV und HCV-RNA-positive schwedische Blutspender (44 Männer, 18 Frauen, Alter im Median 34 Jahre) wurden untersucht. Die HCV-Genotypen wurden in Korrelation gesetzt zu parenteralen Risikofaktoren, Lebermorphologie, Serum-Alanin-Aminotransferase (ALAT)-Spiegeln und HCV-Antikörperprofil. 40% der Spender waren mit dem HCV-Genotyp 1a infiziert, 10% mit 1b, 21% mit 2b und 29% mit 3a. Bei Spendern mit Genotyp 3a bestand häufiger eine Vorgeschichte von intravenösem Drogenabusus als bei den mit Genotyp 1a Infizierten (p=0,024). Bluttransfusionen waren bei Genotyp 2b häufiger vorausgegangen als bei Typ 3a (p=0,012). Bei 38% der mit Genotyp 2b aber nur bei 8% der mit Genotyp 1a infizierten Spender fand sich eine chronisch aktive Hepatitis mit oder ohne Zirrhose (p=0,034). 40% der Spender, die Genotyp 1a aufwiesen, hatten zur Zeit der Leberbiopsie normale ALAT-Werte, bei Genotyp 3a waren es nur 11% (p=0,046). Bei fast allen Spendern waren Antikörper gegen C33c und C22-3 nachzuweisen. Reaktivität gegen C100-3 und 5-1-1 fand sich häufiger bei Spendern mit Genotyp 1a oder 1b als bei Spendern mit Genotyp 2b oder 3a. Zusammenfassend ist festzustellen, daß Genotyp 3a mit intravenösem Drogenabusus oder Tätowierung als Risikofaktoren für eine intravenöse Akquisition der Infektion assoziiert war, Genotyp 2b dagegen mit Bluttransfusionen. Spender mit Genotyp 1a hatten offensichtlich eine weniger schwere Lebererkrankung als Spender, die mit den Genotypen 2b oder 3a infiziert waren. (Less)
Abstract
Sixty-two anti-HCV and HCV-RNA positive Swedish blood donors (44 men, 18 women; median age 34 years) were studied. HCV genotypes were correlated to parenteral risk factors, liver morphology, serum alanine aminotransferase (ALAT) levels and HCV antibody profile. Forty percent of the donors were infected with HCV genotype 1a, 10% with 1b, 21% with 2b, and 29% with 3a. Intravenous drug use (IVDU) was more common in donors with genotype 3a than in those with genotype 1a (p = 0.024), and prior blood transfusion more common in genotype 2b than in 3a (p = 0.012). Chronic active hepatitis with and without cirrhosis was found in 38% of donors infected with genotype 2b as compared to 8% of donors infected with 1a (p = 0.034). Forty percent of donors... (More)
Sixty-two anti-HCV and HCV-RNA positive Swedish blood donors (44 men, 18 women; median age 34 years) were studied. HCV genotypes were correlated to parenteral risk factors, liver morphology, serum alanine aminotransferase (ALAT) levels and HCV antibody profile. Forty percent of the donors were infected with HCV genotype 1a, 10% with 1b, 21% with 2b, and 29% with 3a. Intravenous drug use (IVDU) was more common in donors with genotype 3a than in those with genotype 1a (p = 0.024), and prior blood transfusion more common in genotype 2b than in 3a (p = 0.012). Chronic active hepatitis with and without cirrhosis was found in 38% of donors infected with genotype 2b as compared to 8% of donors infected with 1a (p = 0.034). Forty percent of donors with genotype 1a had normal ALAT at the time of liver biopsy versus 11% with genotype 3a (p = 0.046). Antibodies to C33c and C22-3 were present in nearly all donors whereas reactivity to C100-3 and 5-1-1 was detected more often in donors with genotypes 1a and 1b as compared to donors with genotypes 2b and 3a. In conclusion, genotype 3a was correlated to IVDU or tattooing as parenteral risk factors for the acquisition of HCV infection, and genotype 2b to prior blood transfusion. Donors with genotypes 1a seemed to have less severe liver disease than those infected with genotypes 2b and 3a. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection
volume
23
issue
5
pages
253 - 257
publisher
Urban & Vogel
external identifiers
  • pmid:8557380
  • scopus:0028863218
ISSN
1439-0973
DOI
10.1007/BF01716280
language
English
LU publication?
yes
id
b80f6905-e151-4d21-aa3b-0fcbadacb708 (old id 1108798)
date added to LUP
2008-07-24 16:41:32
date last changed
2017-01-01 06:46:16
@article{b80f6905-e151-4d21-aa3b-0fcbadacb708,
  abstract     = {Sixty-two anti-HCV and HCV-RNA positive Swedish blood donors (44 men, 18 women; median age 34 years) were studied. HCV genotypes were correlated to parenteral risk factors, liver morphology, serum alanine aminotransferase (ALAT) levels and HCV antibody profile. Forty percent of the donors were infected with HCV genotype 1a, 10% with 1b, 21% with 2b, and 29% with 3a. Intravenous drug use (IVDU) was more common in donors with genotype 3a than in those with genotype 1a (p = 0.024), and prior blood transfusion more common in genotype 2b than in 3a (p = 0.012). Chronic active hepatitis with and without cirrhosis was found in 38% of donors infected with genotype 2b as compared to 8% of donors infected with 1a (p = 0.034). Forty percent of donors with genotype 1a had normal ALAT at the time of liver biopsy versus 11% with genotype 3a (p = 0.046). Antibodies to C33c and C22-3 were present in nearly all donors whereas reactivity to C100-3 and 5-1-1 was detected more often in donors with genotypes 1a and 1b as compared to donors with genotypes 2b and 3a. In conclusion, genotype 3a was correlated to IVDU or tattooing as parenteral risk factors for the acquisition of HCV infection, and genotype 2b to prior blood transfusion. Donors with genotypes 1a seemed to have less severe liver disease than those infected with genotypes 2b and 3a.},
  author       = {Shev, S and Widell, Anders and Foberg, U and Fryden, A and Hermodsson, S and Lindh, G and Lindholm, A and Månsson, Siv and Weiland, O and Norkrans, G},
  issn         = {1439-0973},
  language     = {eng},
  number       = {5},
  pages        = {253--257},
  publisher    = {Urban & Vogel},
  series       = {Infection},
  title        = {HCV genotypes in Swedish blood donors as correlated to epidemiology, liver disease and hepatitis C virus antibody profile},
  url          = {http://dx.doi.org/10.1007/BF01716280},
  volume       = {23},
  year         = {1995},
}