Combined alpha-interferon and ribavirin treatment in chronic hepatitis C: a pilot study
(1995) In Scandinavian Journal of Infectious Diseases 27(4). p.325-329- Abstract
- 16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 24 weeks after treatment cessation 9/15 (60%) evaluable patients had complete clearance of HCV-RNA as measured with PCR. HCV genotype did not seem to be correlated with response, but patients with sustained response to treatment had a significantly reduced number of HCV RNA copies/ml serum at treatment start compared with the other patients. These... (More)
- 16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 24 weeks after treatment cessation 9/15 (60%) evaluable patients had complete clearance of HCV-RNA as measured with PCR. HCV genotype did not seem to be correlated with response, but patients with sustained response to treatment had a significantly reduced number of HCV RNA copies/ml serum at treatment start compared with the other patients. These findings support the promising results of this combination therapy noted in other pilot studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108814
- author
- Braconier, Jean Henrik LU ; Paulsen, Otto ; Engman, Katarina and Widell, Anders LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 27
- issue
- 4
- pages
- 325 - 329
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:8658064
- scopus:0029120899
- ISSN
- 1651-1980
- DOI
- 10.3109/00365549509032725
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000), Clinical Microbiology, Malmö (013011000)
- id
- 801bc9bc-af9e-47ce-8108-8427edfa5d45 (old id 1108814)
- date added to LUP
- 2016-04-01 16:36:01
- date last changed
- 2021-09-26 04:22:18
@article{801bc9bc-af9e-47ce-8108-8427edfa5d45, abstract = {{16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 24 weeks after treatment cessation 9/15 (60%) evaluable patients had complete clearance of HCV-RNA as measured with PCR. HCV genotype did not seem to be correlated with response, but patients with sustained response to treatment had a significantly reduced number of HCV RNA copies/ml serum at treatment start compared with the other patients. These findings support the promising results of this combination therapy noted in other pilot studies.}}, author = {{Braconier, Jean Henrik and Paulsen, Otto and Engman, Katarina and Widell, Anders}}, issn = {{1651-1980}}, language = {{eng}}, number = {{4}}, pages = {{325--329}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{Combined alpha-interferon and ribavirin treatment in chronic hepatitis C: a pilot study}}, url = {{http://dx.doi.org/10.3109/00365549509032725}}, doi = {{10.3109/00365549509032725}}, volume = {{27}}, year = {{1995}}, }