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Hepatitis C virus genotypes among blood donors and their recipients in Iceland determined by the polymerase chain reaction

Love, A; Smaradottir, A; Thorsteinsson, S B; Stanzeit, B and Widell, Anders LU (1995) In Vox Sanguinis 69(1). p.18-22
Abstract
Eight antibody-positive individuals were detected among 12,000 blood donations during the first year of screening blood donors for hepatitis C virus (HCV) antibodies in Iceland. All 8 were found to have a history of intravenous drug abuse. Six of these 8 individuals had previously donated blood to 27 patients who could be traced and examined for HCV infection. The great majority (23/27, 85%) of the recipients had demonstrable HCV antibodies. Furthermore, RNA analysis with the polymerase chain reaction showed that all patients with HCV antibodies had HCV RNA in their serum and in one hemodialysis patient without HCV antibodies viral RNA could be demonstrated. Genotyping of the HCV strains showed that the genotype of the donor was also... (More)
Eight antibody-positive individuals were detected among 12,000 blood donations during the first year of screening blood donors for hepatitis C virus (HCV) antibodies in Iceland. All 8 were found to have a history of intravenous drug abuse. Six of these 8 individuals had previously donated blood to 27 patients who could be traced and examined for HCV infection. The great majority (23/27, 85%) of the recipients had demonstrable HCV antibodies. Furthermore, RNA analysis with the polymerase chain reaction showed that all patients with HCV antibodies had HCV RNA in their serum and in one hemodialysis patient without HCV antibodies viral RNA could be demonstrated. Genotyping of the HCV strains showed that the genotype of the donor was also identified in all but one of the infected recipients of his/her blood or blood products. This study, therefore, substantiates high infectivity of the HCV by blood or blood factor donation and shows that viremic HCV antibody-negative individuals exist. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vox Sanguinis
volume
69
issue
1
pages
18 - 22
publisher
Wiley-Blackwell
external identifiers
  • pmid:7483487
  • scopus:0029041851
ISSN
1423-0410
language
English
LU publication?
yes
id
a60da96e-f620-4805-846b-d790b975c8dc (old id 1108844)
date added to LUP
2008-07-24 16:57:11
date last changed
2017-07-09 04:23:26
@article{a60da96e-f620-4805-846b-d790b975c8dc,
  abstract     = {Eight antibody-positive individuals were detected among 12,000 blood donations during the first year of screening blood donors for hepatitis C virus (HCV) antibodies in Iceland. All 8 were found to have a history of intravenous drug abuse. Six of these 8 individuals had previously donated blood to 27 patients who could be traced and examined for HCV infection. The great majority (23/27, 85%) of the recipients had demonstrable HCV antibodies. Furthermore, RNA analysis with the polymerase chain reaction showed that all patients with HCV antibodies had HCV RNA in their serum and in one hemodialysis patient without HCV antibodies viral RNA could be demonstrated. Genotyping of the HCV strains showed that the genotype of the donor was also identified in all but one of the infected recipients of his/her blood or blood products. This study, therefore, substantiates high infectivity of the HCV by blood or blood factor donation and shows that viremic HCV antibody-negative individuals exist.},
  author       = {Love, A and Smaradottir, A and Thorsteinsson, S B and Stanzeit, B and Widell, Anders},
  issn         = {1423-0410},
  language     = {eng},
  number       = {1},
  pages        = {18--22},
  publisher    = {Wiley-Blackwell},
  series       = {Vox Sanguinis},
  title        = {Hepatitis C virus genotypes among blood donors and their recipients in Iceland determined by the polymerase chain reaction},
  volume       = {69},
  year         = {1995},
}