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Experimental evaluation of the effect of filtration of diesel exhaust by biologic exposure indicators

Ulfvarson, U; Dahlqvist, M; Sandstrom, T; Bergstrom, B; Ekholm, U; Lagerstrand, L; Figler, B; Nilsen, A; Bjermer, Leif LU and Tronnes, T (1995) In American Journal of Industrial Medicine 27(1). p.91-106
Abstract
The airway resistance, compliance of the respiratory system, transfer factor, and alveolar volume of 33 healthy rabbits were studied before and after exposure to diluted diesel exhaust generated in an experimental motor. Three diesel fuels and two particle traps were tested. Subsequent to the post-exposure lung function measurements, the animals were sacrificed and the lungs were processed for morphologic examination. The concentrations of particles, nitrogen dioxide, and formaldehyde were measured. The inflammatory airway changes were most pronounced in animals exposed to exhaust from standard fuel. Small changes were identified in animals exposed to exhaust filtered through the catalytic trap as well or exposed to unfiltered exhaust from... (More)
The airway resistance, compliance of the respiratory system, transfer factor, and alveolar volume of 33 healthy rabbits were studied before and after exposure to diluted diesel exhaust generated in an experimental motor. Three diesel fuels and two particle traps were tested. Subsequent to the post-exposure lung function measurements, the animals were sacrificed and the lungs were processed for morphologic examination. The concentrations of particles, nitrogen dioxide, and formaldehyde were measured. The inflammatory airway changes were most pronounced in animals exposed to exhaust from standard fuel. Small changes were identified in animals exposed to exhaust filtered through the catalytic trap as well or exposed to unfiltered exhaust from fuels intended for densely built-up areas. Increase in compliance of the respiratory system was associated with the concentration of soot particles and formaldehyde. Compliance decreased significantly in animals exposed to exhaust from standard fuel filtered through the particle traps and increased almost significantly in animals exposed to unfiltered exhaust from the same fuel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
soot particles, diesel particulates, formaldehyde, nitrogen dioxide, acute pulmonary function effects, static compliance, airway resistance
in
American Journal of Industrial Medicine
volume
27
issue
1
pages
91 - 106
publisher
John Wiley & Sons
external identifiers
  • pmid:7900738
  • scopus:0028817471
ISSN
0271-3586
DOI
10.1002/ajim.4700270109
language
English
LU publication?
yes
id
2d985af7-7a12-4528-865a-ff768d0ad7a3 (old id 1108923)
date added to LUP
2008-07-25 11:14:39
date last changed
2017-07-30 03:51:10
@article{2d985af7-7a12-4528-865a-ff768d0ad7a3,
  abstract     = {The airway resistance, compliance of the respiratory system, transfer factor, and alveolar volume of 33 healthy rabbits were studied before and after exposure to diluted diesel exhaust generated in an experimental motor. Three diesel fuels and two particle traps were tested. Subsequent to the post-exposure lung function measurements, the animals were sacrificed and the lungs were processed for morphologic examination. The concentrations of particles, nitrogen dioxide, and formaldehyde were measured. The inflammatory airway changes were most pronounced in animals exposed to exhaust from standard fuel. Small changes were identified in animals exposed to exhaust filtered through the catalytic trap as well or exposed to unfiltered exhaust from fuels intended for densely built-up areas. Increase in compliance of the respiratory system was associated with the concentration of soot particles and formaldehyde. Compliance decreased significantly in animals exposed to exhaust from standard fuel filtered through the particle traps and increased almost significantly in animals exposed to unfiltered exhaust from the same fuel.},
  author       = {Ulfvarson, U and Dahlqvist, M and Sandstrom, T and Bergstrom, B and Ekholm, U and Lagerstrand, L and Figler, B and Nilsen, A and Bjermer, Leif and Tronnes, T},
  issn         = {0271-3586},
  keyword      = {soot particles,diesel particulates,formaldehyde,nitrogen dioxide,acute pulmonary function effects,static compliance,airway resistance},
  language     = {eng},
  number       = {1},
  pages        = {91--106},
  publisher    = {John Wiley & Sons},
  series       = {American Journal of Industrial Medicine},
  title        = {Experimental evaluation of the effect of filtration of diesel exhaust by biologic exposure indicators},
  url          = {http://dx.doi.org/10.1002/ajim.4700270109},
  volume       = {27},
  year         = {1995},
}