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Contrast-enhanced MRI of the central nervous system: comparison between gadodiamide injection and gadolinium-DTPA

Åkeson, Per LU ; Jonsson, E; Haugen, I and Holtås, Stig LU (1995) In Neuroradiology 37(3). p.229-233
Abstract
Gadodiamide injection, a new nonionic, MRI contrast medium, was compared with the ionic agent gadolinium (Gd)-DTPA at 0.1 mmol/kg body weight in a double-blind, randomised trial in 60 patients, 30 receiving each substance, with known or suspected lesions of the central nervous system. The patients were closely questioned about adverse events. In the Gadodiamide injection group, four patients reported six adverse advents, three of which were judged to be related to the contrast medium. In the Gd-DTPA group, two patients each reported one adverse event, both of which had an uncertain relation to the contrast medium. All events were mild and no medical treatment was needed. No significant change in neurological findings, blood pressure, pulse... (More)
Gadodiamide injection, a new nonionic, MRI contrast medium, was compared with the ionic agent gadolinium (Gd)-DTPA at 0.1 mmol/kg body weight in a double-blind, randomised trial in 60 patients, 30 receiving each substance, with known or suspected lesions of the central nervous system. The patients were closely questioned about adverse events. In the Gadodiamide injection group, four patients reported six adverse advents, three of which were judged to be related to the contrast medium. In the Gd-DTPA group, two patients each reported one adverse event, both of which had an uncertain relation to the contrast medium. All events were mild and no medical treatment was needed. No significant change in neurological findings, blood pressure, pulse rate or blood parameters were noted in any patient. Both contrast media were effective; no difference in overall efficacy or safety was observed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain, MRI · Spine, MRI · Gadolinium contrast media
in
Neuroradiology
volume
37
issue
3
pages
229 - 233
publisher
Springer Verlag
external identifiers
  • pmid:7603600
  • scopus:0028960218
ISSN
1432-1920
DOI
10.1007/BF01578263
language
English
LU publication?
yes
id
69763e76-d20b-465e-a703-16eb4e9d4fe3 (old id 1109289)
date added to LUP
2008-07-28 09:27:59
date last changed
2017-07-30 03:44:48
@article{69763e76-d20b-465e-a703-16eb4e9d4fe3,
  abstract     = {Gadodiamide injection, a new nonionic, MRI contrast medium, was compared with the ionic agent gadolinium (Gd)-DTPA at 0.1 mmol/kg body weight in a double-blind, randomised trial in 60 patients, 30 receiving each substance, with known or suspected lesions of the central nervous system. The patients were closely questioned about adverse events. In the Gadodiamide injection group, four patients reported six adverse advents, three of which were judged to be related to the contrast medium. In the Gd-DTPA group, two patients each reported one adverse event, both of which had an uncertain relation to the contrast medium. All events were mild and no medical treatment was needed. No significant change in neurological findings, blood pressure, pulse rate or blood parameters were noted in any patient. Both contrast media were effective; no difference in overall efficacy or safety was observed.},
  author       = {Åkeson, Per and Jonsson, E and Haugen, I and Holtås, Stig},
  issn         = {1432-1920},
  keyword      = {Brain,MRI · Spine,MRI · Gadolinium contrast media},
  language     = {eng},
  number       = {3},
  pages        = {229--233},
  publisher    = {Springer Verlag},
  series       = {Neuroradiology},
  title        = {Contrast-enhanced MRI of the central nervous system: comparison between gadodiamide injection and gadolinium-DTPA},
  url          = {http://dx.doi.org/10.1007/BF01578263},
  volume       = {37},
  year         = {1995},
}