A porcine model for evaluation of cerebral haemodynamics and metabolism during increased intracranial pressure
(1995) In Acta Anaesthesiologica Scandinavica 39(6). p.827-834- Abstract
- In patients with severe head injuries raised intracranial pressure (ICP) constitutes the most important cause of mortality. Several new therapies for increased ICP have recently been suggested and it is of importance to study the physiological effects of these treatments in animal experiments during steady state conditions. A porcine model for evaluation of cerebral haemodynamics and metabolism during increased ICP is presented. Intracranial hypertension was induced by inflation of two tonometric gastric balloons placed extradurally covering a major part of the parietooccipital region bilaterally. The distribution of the blood flow supplied by the carotid artery used for the cerebral blood flow (CBF) measurements was studied by... (More)
- In patients with severe head injuries raised intracranial pressure (ICP) constitutes the most important cause of mortality. Several new therapies for increased ICP have recently been suggested and it is of importance to study the physiological effects of these treatments in animal experiments during steady state conditions. A porcine model for evaluation of cerebral haemodynamics and metabolism during increased ICP is presented. Intracranial hypertension was induced by inflation of two tonometric gastric balloons placed extradurally covering a major part of the parietooccipital region bilaterally. The distribution of the blood flow supplied by the carotid artery used for the cerebral blood flow (CBF) measurements was studied by intraarterial (i.a.) injection of 99mTc-HMPAO. The measurements showed that following ligation of the external carotid and the occipital artery no accumulation of tracer substance occurred in extracranial tissues during normal or increased ICP. Cerebral physiological variables (CBF, Cavo2, and ICP) were measured 5, 20 and 60 min after induction of intracranial hypertension. The results confirm that the experimental situation gives a reproducible increase in ICP (25-28 mm Hg) and that the physiological variables remain stable during the period of intracranial hypertension. We conclude that the model simulates the effects of an acute intracranial focal mass and is well suited for the evaluation of different pharmacological therapies of increased ICP. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109376
- author
- Nilsson, F ; Åkeson, Jonas LU ; Messeter, K ; Ryding, E ; Rosén, Ingmar LU and Nordström, Carl-Henrik LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 39
- issue
- 6
- pages
- 827 - 834
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:7484043
- scopus:0029022026
- ISSN
- 0001-5172
- language
- English
- LU publication?
- yes
- id
- 9af85998-ede7-46c9-9342-e78c6f3fdca9 (old id 1109376)
- date added to LUP
- 2016-04-01 11:48:29
- date last changed
- 2021-01-03 06:25:22
@article{9af85998-ede7-46c9-9342-e78c6f3fdca9, abstract = {{In patients with severe head injuries raised intracranial pressure (ICP) constitutes the most important cause of mortality. Several new therapies for increased ICP have recently been suggested and it is of importance to study the physiological effects of these treatments in animal experiments during steady state conditions. A porcine model for evaluation of cerebral haemodynamics and metabolism during increased ICP is presented. Intracranial hypertension was induced by inflation of two tonometric gastric balloons placed extradurally covering a major part of the parietooccipital region bilaterally. The distribution of the blood flow supplied by the carotid artery used for the cerebral blood flow (CBF) measurements was studied by intraarterial (i.a.) injection of 99mTc-HMPAO. The measurements showed that following ligation of the external carotid and the occipital artery no accumulation of tracer substance occurred in extracranial tissues during normal or increased ICP. Cerebral physiological variables (CBF, Cavo2, and ICP) were measured 5, 20 and 60 min after induction of intracranial hypertension. The results confirm that the experimental situation gives a reproducible increase in ICP (25-28 mm Hg) and that the physiological variables remain stable during the period of intracranial hypertension. We conclude that the model simulates the effects of an acute intracranial focal mass and is well suited for the evaluation of different pharmacological therapies of increased ICP.}}, author = {{Nilsson, F and Åkeson, Jonas and Messeter, K and Ryding, E and Rosén, Ingmar and Nordström, Carl-Henrik}}, issn = {{0001-5172}}, language = {{eng}}, number = {{6}}, pages = {{827--834}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Anaesthesiologica Scandinavica}}, title = {{A porcine model for evaluation of cerebral haemodynamics and metabolism during increased intracranial pressure}}, volume = {{39}}, year = {{1995}}, }