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Airway effects of salmeterol in healthy individuals

Bergendal, Anna; Johansson, Åke; Bake, Björn; Lotvall, Jan; Skoogh, Bengt-Eric and Löfdahl, Claes-Göran LU (1995) In Pulmonary Pharmacology 8(6). p.283-288
Abstract
The long-acting beta 2-agonist salmeterol has been shown in several in vitro studies to produce non-beta-mediated relaxant effects. The aim of the present study was to investigate whether these effects have any relevance in humans in vivo. Thirteen healthy individuals were studied in a randomized, double-blind, cross-over study on five separate days. The subjects were pre-treated orally with either propranolol 400 mg in order to block beta-adrenoceptor mediated effects or placebo. Two hours after drug intake, three increasing doses of salmeterol (25 + 50 + 100 micrograms), salbutamol (100 + 200 + 400 micrograms) or placebo were given from matched meter dose inhalers at 1-h intervals between doses. Specific airway conductance (sGAW) was... (More)
The long-acting beta 2-agonist salmeterol has been shown in several in vitro studies to produce non-beta-mediated relaxant effects. The aim of the present study was to investigate whether these effects have any relevance in humans in vivo. Thirteen healthy individuals were studied in a randomized, double-blind, cross-over study on five separate days. The subjects were pre-treated orally with either propranolol 400 mg in order to block beta-adrenoceptor mediated effects or placebo. Two hours after drug intake, three increasing doses of salmeterol (25 + 50 + 100 micrograms), salbutamol (100 + 200 + 400 micrograms) or placebo were given from matched meter dose inhalers at 1-h intervals between doses. Specific airway conductance (sGAW) was measured in a body plethysmograph at the beginning of the experiment and 30 and 60 min after each inhaled dose of the beta-agonists. Salmeterol and salbutamol produced the same maximal increase in sGAW and had the same area under the dose-response curves. Pre-treatment with propranolol totally inhibited the effect of both drugs. In conclusion, salmeterol at clinically used doses did not produce any non-beta-mediated bronchodilating effect in normal individuals, measured as sGAW. Salmeterol and salbutamol showed the same efficacy but salmeterol was four times more potent than salbutamol. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Salmeterol, sGAw, Potency, Non-β-mediated relaxation, Salbutamol
in
Pulmonary Pharmacology
volume
8
issue
6
pages
283 - 288
publisher
Elsevier
external identifiers
  • pmid:8819183
  • scopus:0029556603
ISSN
0952-0600
DOI
10.1006/pulp.1995.1038
language
English
LU publication?
yes
id
e94fa116-d5a2-4530-bceb-b1e4fae104d0 (old id 1109390)
date added to LUP
2008-07-28 14:03:09
date last changed
2017-01-01 07:21:32
@article{e94fa116-d5a2-4530-bceb-b1e4fae104d0,
  abstract     = {The long-acting beta 2-agonist salmeterol has been shown in several in vitro studies to produce non-beta-mediated relaxant effects. The aim of the present study was to investigate whether these effects have any relevance in humans in vivo. Thirteen healthy individuals were studied in a randomized, double-blind, cross-over study on five separate days. The subjects were pre-treated orally with either propranolol 400 mg in order to block beta-adrenoceptor mediated effects or placebo. Two hours after drug intake, three increasing doses of salmeterol (25 + 50 + 100 micrograms), salbutamol (100 + 200 + 400 micrograms) or placebo were given from matched meter dose inhalers at 1-h intervals between doses. Specific airway conductance (sGAW) was measured in a body plethysmograph at the beginning of the experiment and 30 and 60 min after each inhaled dose of the beta-agonists. Salmeterol and salbutamol produced the same maximal increase in sGAW and had the same area under the dose-response curves. Pre-treatment with propranolol totally inhibited the effect of both drugs. In conclusion, salmeterol at clinically used doses did not produce any non-beta-mediated bronchodilating effect in normal individuals, measured as sGAW. Salmeterol and salbutamol showed the same efficacy but salmeterol was four times more potent than salbutamol.},
  author       = {Bergendal, Anna and Johansson, Åke and Bake, Björn and Lotvall, Jan and Skoogh, Bengt-Eric and Löfdahl, Claes-Göran},
  issn         = {0952-0600},
  keyword      = {Salmeterol,sGAw,Potency,Non-β-mediated relaxation,Salbutamol},
  language     = {eng},
  number       = {6},
  pages        = {283--288},
  publisher    = {Elsevier},
  series       = {Pulmonary Pharmacology},
  title        = {Airway effects of salmeterol in healthy individuals},
  url          = {http://dx.doi.org/10.1006/pulp.1995.1038},
  volume       = {8},
  year         = {1995},
}