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Reducing arrhythmogenic effects in the isolated heart enriching roentgen contrast media with electrolytes. Survey and present state

Besjakov, Jack LU and Bååth, Lars LU (1995) In Acta Radiologica. Supplementum 399. p.115-121
Abstract
A review of the literature on the effects of adding electrolytes to ionic as well as nonionic contrast media (CM) in the isolated heart model reveals that both ionic and nonionic CM favor from such addtion, if the added electrolytes are balanced with respect to each other. By enriching nonionic monomeric as well as dimeric CM with such a balanced electrolyte solution, the risk of ventricular fibrillation is reduced and myocardial contractibility is improved compared to nonionic CM without such enrichment. The new nonionic dimer iodixanol is slightly hypotonic to plasma in concentrations suitable for coronary arteriography. The water solution of iodixanol therefore contains an osmotic space in which electrolytes can be added, therby making... (More)
A review of the literature on the effects of adding electrolytes to ionic as well as nonionic contrast media (CM) in the isolated heart model reveals that both ionic and nonionic CM favor from such addtion, if the added electrolytes are balanced with respect to each other. By enriching nonionic monomeric as well as dimeric CM with such a balanced electrolyte solution, the risk of ventricular fibrillation is reduced and myocardial contractibility is improved compared to nonionic CM without such enrichment. The new nonionic dimer iodixanol is slightly hypotonic to plasma in concentrations suitable for coronary arteriography. The water solution of iodixanol therefore contains an osmotic space in which electrolytes can be added, therby making it isotonic with plasma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica. Supplementum
volume
399
pages
115 - 121
publisher
Munksgaard International Publishers
external identifiers
  • pmid:8610505
  • scopus:0029442577
ISSN
0365-5954
language
English
LU publication?
yes
id
0a47efa7-426f-45b2-a18d-155e05e7feb4 (old id 1109481)
date added to LUP
2008-07-28 15:47:16
date last changed
2017-01-01 06:59:31
@article{0a47efa7-426f-45b2-a18d-155e05e7feb4,
  abstract     = {A review of the literature on the effects of adding electrolytes to ionic as well as nonionic contrast media (CM) in the isolated heart model reveals that both ionic and nonionic CM favor from such addtion, if the added electrolytes are balanced with respect to each other. By enriching nonionic monomeric as well as dimeric CM with such a balanced electrolyte solution, the risk of ventricular fibrillation is reduced and myocardial contractibility is improved compared to nonionic CM without such enrichment. The new nonionic dimer iodixanol is slightly hypotonic to plasma in concentrations suitable for coronary arteriography. The water solution of iodixanol therefore contains an osmotic space in which electrolytes can be added, therby making it isotonic with plasma.},
  author       = {Besjakov, Jack and Bååth, Lars},
  issn         = {0365-5954},
  language     = {eng},
  pages        = {115--121},
  publisher    = {Munksgaard International Publishers},
  series       = {Acta Radiologica. Supplementum},
  title        = {Reducing arrhythmogenic effects in the isolated heart enriching roentgen contrast media with electrolytes. Survey and present state},
  volume       = {399},
  year         = {1995},
}