Advanced

Dental amalgam, low-dose exposure to mercury, and urinary proteins in young Swedish men

Herrstrom, Per; Schutz, A; Raihle, G; Holthuis, N; Hogstedt, B and Råstam, Lennart LU (1995) In Archives of Environmental Health 50(2). p.103-108
Abstract
Chronic exposure to inorganic mercury can cause kidney injury. Evidence gained from occupational medicine indicates that individuals who are exposed to only environmental sources, including amalgam tooth fillings, are at very little risk. Animal experiments, however, have revealed glomerular lesions of immunologic origin after low-dose exposure to inorganic mercury. In this study, the association between the number of amalgam tooth surfaces, urinary mercury, and proteinuria was explored in a sample of 48 randomly selected, apparently healthy male students who were 17-22 y of age. Presence of any of the following proteins in two separate urine samples was considered to be potentially indicative of any tubular and/or glomerular lesion:... (More)
Chronic exposure to inorganic mercury can cause kidney injury. Evidence gained from occupational medicine indicates that individuals who are exposed to only environmental sources, including amalgam tooth fillings, are at very little risk. Animal experiments, however, have revealed glomerular lesions of immunologic origin after low-dose exposure to inorganic mercury. In this study, the association between the number of amalgam tooth surfaces, urinary mercury, and proteinuria was explored in a sample of 48 randomly selected, apparently healthy male students who were 17-22 y of age. Presence of any of the following proteins in two separate urine samples was considered to be potentially indicative of any tubular and/or glomerular lesion: albumin, alpha-1-microglobulin (HC-protein), kappa and lambda light chains, and N-acetyl-beta-D-glucosaminidase. No significant relationship was found between any of the proteins and amalgam or urinary mercury. The results of this study did not suggest that amalgam fillings cause kidney dysfunction in humans. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Environmental Health
volume
50
issue
2
pages
103 - 108
publisher
Heldref Publications
external identifiers
  • pmid:7786045
  • scopus:0029072156
ISSN
0003-9896
language
English
LU publication?
yes
id
2101ec31-5702-44ff-808e-13af4c8d31ac (old id 1109616)
date added to LUP
2008-07-29 11:36:14
date last changed
2017-01-22 04:02:49
@article{2101ec31-5702-44ff-808e-13af4c8d31ac,
  abstract     = {Chronic exposure to inorganic mercury can cause kidney injury. Evidence gained from occupational medicine indicates that individuals who are exposed to only environmental sources, including amalgam tooth fillings, are at very little risk. Animal experiments, however, have revealed glomerular lesions of immunologic origin after low-dose exposure to inorganic mercury. In this study, the association between the number of amalgam tooth surfaces, urinary mercury, and proteinuria was explored in a sample of 48 randomly selected, apparently healthy male students who were 17-22 y of age. Presence of any of the following proteins in two separate urine samples was considered to be potentially indicative of any tubular and/or glomerular lesion: albumin, alpha-1-microglobulin (HC-protein), kappa and lambda light chains, and N-acetyl-beta-D-glucosaminidase. No significant relationship was found between any of the proteins and amalgam or urinary mercury. The results of this study did not suggest that amalgam fillings cause kidney dysfunction in humans.},
  author       = {Herrstrom, Per and Schutz, A and Raihle, G and Holthuis, N and Hogstedt, B and Råstam, Lennart},
  issn         = {0003-9896},
  language     = {eng},
  number       = {2},
  pages        = {103--108},
  publisher    = {Heldref Publications},
  series       = {Archives of Environmental Health},
  title        = {Dental amalgam, low-dose exposure to mercury, and urinary proteins in young Swedish men},
  volume       = {50},
  year         = {1995},
}