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Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men

Lind, L; Hanni, A; Lithell, H; Hvarfner, Andreas LU ; Sorensen, O H and Ljunghall, S (1995) In American Journal of Hypertension 8(9). p.894-901
Abstract
A previous study has shown that serum levels of the active vitamin D metabolite 1,25-(OH)2-vitamin D were inversely related to blood pressure levels while the prohormone 25-OH-vitamin D was found to be related to insulin metabolism. Also other clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes. The present study was conducted in order to see if the above mentioned relationships between the vitamin D endocrine system and blood pressure, as well as other cardiovascular risk factors, could be found in a cross-section population-based study. Serum levels of 1,25-(OH)2-vitamin D, 25-OH-vitamin D, and blood pressure were therefore measured in 34... (More)
A previous study has shown that serum levels of the active vitamin D metabolite 1,25-(OH)2-vitamin D were inversely related to blood pressure levels while the prohormone 25-OH-vitamin D was found to be related to insulin metabolism. Also other clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes. The present study was conducted in order to see if the above mentioned relationships between the vitamin D endocrine system and blood pressure, as well as other cardiovascular risk factors, could be found in a cross-section population-based study. Serum levels of 1,25-(OH)2-vitamin D, 25-OH-vitamin D, and blood pressure were therefore measured in 34 middle-aged men and metabolic cardiovascular risk factors were evaluated by means of intravenous glucose and fat tolerance tests, euglycemic hyperinsulinemic clamp, lipoprotein measurements, and lipoprotein lipase activity determinations. Serum levels of 1,25-(OH)2-vitamin D were found to be inversely correlated to the blood pressure (r = -0.42, P < .02), VLDL triglycerides (r = -0.47, P < .005), and to triglyceride removal at the intravenous fat tolerance test (r = 0.34, P < .05), while serum levels of 25-OH-vitamin D were correlated to fasting insulin (r = -0.35, P < .05), insulin sensitivity during clamp (r = 0.54, P < .001), and lipoprotein lipase activity both in adiposal tissue (r = 0.48, P < .005) and skeletal muscle (r = 0.38, P < .03).(ABSTRACT TRUNCATED AT 250 WORDS) (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Calcium, vitamin D, magnesium, insulin, glucose, lipids, triglycerides
in
American Journal of Hypertension
volume
8
issue
9
pages
894 - 901
publisher
Elsevier
external identifiers
  • pmid:8541004
  • scopus:0029156145
ISSN
1941-7225
DOI
10.1016/0895-7061(95)00154-H
language
English
LU publication?
no
id
4c50c9c8-1302-4083-a6a8-3b0a136ed53e (old id 1109659)
date added to LUP
2008-07-29 12:44:28
date last changed
2017-07-02 03:39:02
@article{4c50c9c8-1302-4083-a6a8-3b0a136ed53e,
  abstract     = {A previous study has shown that serum levels of the active vitamin D metabolite 1,25-(OH)2-vitamin D were inversely related to blood pressure levels while the prohormone 25-OH-vitamin D was found to be related to insulin metabolism. Also other clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes. The present study was conducted in order to see if the above mentioned relationships between the vitamin D endocrine system and blood pressure, as well as other cardiovascular risk factors, could be found in a cross-section population-based study. Serum levels of 1,25-(OH)2-vitamin D, 25-OH-vitamin D, and blood pressure were therefore measured in 34 middle-aged men and metabolic cardiovascular risk factors were evaluated by means of intravenous glucose and fat tolerance tests, euglycemic hyperinsulinemic clamp, lipoprotein measurements, and lipoprotein lipase activity determinations. Serum levels of 1,25-(OH)2-vitamin D were found to be inversely correlated to the blood pressure (r = -0.42, P &lt; .02), VLDL triglycerides (r = -0.47, P &lt; .005), and to triglyceride removal at the intravenous fat tolerance test (r = 0.34, P &lt; .05), while serum levels of 25-OH-vitamin D were correlated to fasting insulin (r = -0.35, P &lt; .05), insulin sensitivity during clamp (r = 0.54, P &lt; .001), and lipoprotein lipase activity both in adiposal tissue (r = 0.48, P &lt; .005) and skeletal muscle (r = 0.38, P &lt; .03).(ABSTRACT TRUNCATED AT 250 WORDS)},
  author       = {Lind, L and Hanni, A and Lithell, H and Hvarfner, Andreas and Sorensen, O H and Ljunghall, S},
  issn         = {1941-7225},
  keyword      = {Calcium,vitamin D,magnesium,insulin,glucose,lipids,triglycerides},
  language     = {eng},
  number       = {9},
  pages        = {894--901},
  publisher    = {Elsevier},
  series       = {American Journal of Hypertension},
  title        = {Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men},
  url          = {http://dx.doi.org/10.1016/0895-7061(95)00154-H},
  volume       = {8},
  year         = {1995},
}