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Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study

Wide-Swensson, Dag LU ; Ingemarsson, Ingemar LU ; Lunell, Nils-Olov; Forman, Axel; Skajaa, Kristijar; Lindberg, Bo; Lindeberg, Solveig; Marsal, Karel LU and Andersson, Karl-Erik LU (1995) In American Journal of Obstetrics and Gynecology 173(3 Pt 1). p.872-878
Abstract
OBJECTIVE: Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy. STUDY DESIGN: The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine versus placebo. Fifty-four women were randomized to treatment with isradipine slow-release capsules given orally 5 mg twice a day and 57 to a placebo group. RESULTS: Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment. Blood flow in the umbilical artery and maternal renal and liver function were... (More)
OBJECTIVE: Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy. STUDY DESIGN: The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine versus placebo. Fifty-four women were randomized to treatment with isradipine slow-release capsules given orally 5 mg twice a day and 57 to a placebo group. RESULTS: Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment. Blood flow in the umbilical artery and maternal renal and liver function were not influenced by treatment. Isradipine had few side effects and was well tolerated. CONCLUSION: Calcium channel blockade with isradipine is effective for treatment of nonproteinuric hypertension but not in preeclampsia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Isradipine, pregnancy, hypertension, preeclampsia, drugs, treatment
in
American Journal of Obstetrics and Gynecology
volume
173
issue
3 Pt 1
pages
872 - 878
publisher
Elsevier
external identifiers
  • pmid:7573260
  • scopus:0029087206
ISSN
1097-6868
DOI
10.1016/0002-9378(95)90357-7
language
English
LU publication?
yes
id
32e0e3d9-fdac-4c24-a4ec-df6ca81da9a0 (old id 1109692)
date added to LUP
2008-07-29 13:39:27
date last changed
2017-10-29 03:30:05
@article{32e0e3d9-fdac-4c24-a4ec-df6ca81da9a0,
  abstract     = {OBJECTIVE: Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy. STUDY DESIGN: The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine versus placebo. Fifty-four women were randomized to treatment with isradipine slow-release capsules given orally 5 mg twice a day and 57 to a placebo group. RESULTS: Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment. Blood flow in the umbilical artery and maternal renal and liver function were not influenced by treatment. Isradipine had few side effects and was well tolerated. CONCLUSION: Calcium channel blockade with isradipine is effective for treatment of nonproteinuric hypertension but not in preeclampsia.},
  author       = {Wide-Swensson, Dag and Ingemarsson, Ingemar and Lunell, Nils-Olov and Forman, Axel and Skajaa, Kristijar and Lindberg, Bo and Lindeberg, Solveig and Marsal, Karel and Andersson, Karl-Erik},
  issn         = {1097-6868},
  keyword      = {Isradipine,pregnancy,hypertension,preeclampsia,drugs,treatment},
  language     = {eng},
  number       = {3 Pt 1},
  pages        = {872--878},
  publisher    = {Elsevier},
  series       = {American Journal of Obstetrics and Gynecology},
  title        = {Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study},
  url          = {http://dx.doi.org/10.1016/0002-9378(95)90357-7},
  volume       = {173},
  year         = {1995},
}