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Standpoint on imprinting of BCR and ABL

Fioretos, Thoas LU ; Heisterkamp, N and Groffen, J (1995) In Leukemia 9(4). p.743-744
Abstract
Cytogenetic studies of Ph-positive leukemic patients and their parents have indicated that chromosome 22 involved in the formation of the t(9;22) is of maternal origin, whereas chromosome 9 is preferentially of paternal origin. These data have suggested that the two genes BCR and ABL, which become fused through the translocation, might be imprinted, ie expressed in a parental-specific manner. Recent molecular genetic studies however, have shown that BCR and ABL are expressed on both alleles and that the maternal and paternal ABL genes contribute equally often to the BCR-ABL fusion messenger. The findings make imprinting of these genes unlikely as an explanatory model and necessitate a combined cytogenetic and molecular genetic study.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
9
issue
4
pages
743 - 744
publisher
Nature Publishing Group
external identifiers
  • pmid:7723414
  • scopus:0028917253
ISSN
1476-5551
language
English
LU publication?
yes
id
fedc80ed-1fcd-44d8-956f-278f715da708 (old id 1109813)
date added to LUP
2008-07-29 15:55:48
date last changed
2017-01-01 06:43:13
@article{fedc80ed-1fcd-44d8-956f-278f715da708,
  abstract     = {Cytogenetic studies of Ph-positive leukemic patients and their parents have indicated that chromosome 22 involved in the formation of the t(9;22) is of maternal origin, whereas chromosome 9 is preferentially of paternal origin. These data have suggested that the two genes BCR and ABL, which become fused through the translocation, might be imprinted, ie expressed in a parental-specific manner. Recent molecular genetic studies however, have shown that BCR and ABL are expressed on both alleles and that the maternal and paternal ABL genes contribute equally often to the BCR-ABL fusion messenger. The findings make imprinting of these genes unlikely as an explanatory model and necessitate a combined cytogenetic and molecular genetic study.},
  author       = {Fioretos, Thoas and Heisterkamp, N and Groffen, J},
  issn         = {1476-5551},
  language     = {eng},
  number       = {4},
  pages        = {743--744},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia},
  title        = {Standpoint on imprinting of BCR and ABL},
  volume       = {9},
  year         = {1995},
}