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Regional localization and developmental expression of the BCR gene in rodent brain

Fioretos, Thoas LU ; Voncken, J W; Baram, T Z; Kamme, F; Groffen, J and Heisterkamp, N (1995) In Cellular & molecular biology research 41(2). p.97-102
Abstract
The BCR gene is implicated in the development of Ph-positive leukemia through its fusion with the nonreceptor tyrosine kinase gene ABL. The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the regulation of respiratory burst activity in white blood cells. Bcr expression levels are relatively constant throughout mouse development until adulthood in brain and in hematopoietic tissues, a pattern that is distinctly different from that of the functionally related n-chimerin gene. In the present study, RNA in situ hybridization was used to explore the normal cellular function of Bcr in rodent brain and hematopoietic organs. The data pinpoint the high bcr expression in the brain... (More)
The BCR gene is implicated in the development of Ph-positive leukemia through its fusion with the nonreceptor tyrosine kinase gene ABL. The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the regulation of respiratory burst activity in white blood cells. Bcr expression levels are relatively constant throughout mouse development until adulthood in brain and in hematopoietic tissues, a pattern that is distinctly different from that of the functionally related n-chimerin gene. In the present study, RNA in situ hybridization was used to explore the normal cellular function of Bcr in rodent brain and hematopoietic organs. The data pinpoint the high bcr expression in the brain to the hippocampal pyramidal cell layer and the dentate gyrus, and to the piriform cortex and the olfactory nuclei, reflecting a potentially interesting function for Bcr in these highly specialized brain regions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular & molecular biology research
volume
41
issue
2
pages
97 - 102
publisher
Elsevier
external identifiers
  • pmid:8581068
  • scopus:0029087642
ISSN
0968-8773
language
English
LU publication?
yes
id
6939d08a-7431-491e-9f57-0be6bd919af5 (old id 1109816)
date added to LUP
2008-07-29 16:04:12
date last changed
2017-01-01 07:02:09
@article{6939d08a-7431-491e-9f57-0be6bd919af5,
  abstract     = {The BCR gene is implicated in the development of Ph-positive leukemia through its fusion with the nonreceptor tyrosine kinase gene ABL. The normal 160 kDa Bcr protein has several functional domains, and recently one specific role for Bcr was established in the regulation of respiratory burst activity in white blood cells. Bcr expression levels are relatively constant throughout mouse development until adulthood in brain and in hematopoietic tissues, a pattern that is distinctly different from that of the functionally related n-chimerin gene. In the present study, RNA in situ hybridization was used to explore the normal cellular function of Bcr in rodent brain and hematopoietic organs. The data pinpoint the high bcr expression in the brain to the hippocampal pyramidal cell layer and the dentate gyrus, and to the piriform cortex and the olfactory nuclei, reflecting a potentially interesting function for Bcr in these highly specialized brain regions.},
  author       = {Fioretos, Thoas and Voncken, J W and Baram, T Z and Kamme, F and Groffen, J and Heisterkamp, N},
  issn         = {0968-8773},
  language     = {eng},
  number       = {2},
  pages        = {97--102},
  publisher    = {Elsevier},
  series       = {Cellular & molecular biology research},
  title        = {Regional localization and developmental expression of the BCR gene in rodent brain},
  volume       = {41},
  year         = {1995},
}