Advanced

Preoperative fine needle aspiration from human breast cancer is a valuable sampling material for progesterone receptor and cytometric DNA analysis

Fernö, Mårten LU ; Baldetorp, Bo LU ; Fallenius, Ghita; Idvall, Ingrid LU ; Johansson, Ulla LU and Killander, Dick LU (1996) In Acta Oncologica 35(S8). p.19-25
Abstract
In a breast cancer series (n = 54), preoperative fine needle aspiration (FNA) was compared with biopsy at primary surgery as a source of material for the determination of progesterone receptor (PgR) content by enzyme immuno assay. The respective results manifested a strong correlation (r(s) = 0.82). The fact that PgR content was usually higher in FNA samples than in the corresponding biopsy samples and the finding that 11% of the tumours were PgR positive in FNA but PgR negative in the corresponding biopsy samples suggest a greater proportion of malignant cells to be obtained with FNA than in surgical biopsy. In another breast cancer series (n = 50), corresponding comparisons for DNA flow cytometry showed concordance in ploidy status... (More)
In a breast cancer series (n = 54), preoperative fine needle aspiration (FNA) was compared with biopsy at primary surgery as a source of material for the determination of progesterone receptor (PgR) content by enzyme immuno assay. The respective results manifested a strong correlation (r(s) = 0.82). The fact that PgR content was usually higher in FNA samples than in the corresponding biopsy samples and the finding that 11% of the tumours were PgR positive in FNA but PgR negative in the corresponding biopsy samples suggest a greater proportion of malignant cells to be obtained with FNA than in surgical biopsy. In another breast cancer series (n = 50), corresponding comparisons for DNA flow cytometry showed concordance in ploidy status (diploid vs. non-diploid) in 84% of cases and a strong correlation in S-phase fraction values (r(s) = 0.70). At DNA image cytometry, concordant results (Auer I + II vs. Auer III + IV) were obtained in 87% of the cases. To sum up, FNA seems to be a useful sampling technique for PgR determination and DNA cytometry. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
35
issue
S8
pages
19 - 25
publisher
Taylor & Francis
external identifiers
  • pmid:9073045
  • scopus:0030426631
ISSN
1651-226X
DOI
10.3109/02841869609098517
language
English
LU publication?
yes
id
8f8a9fff-fdeb-48ec-b99e-c7c194051868 (old id 1110088)
date added to LUP
2008-07-23 09:20:19
date last changed
2017-01-01 07:26:39
@article{8f8a9fff-fdeb-48ec-b99e-c7c194051868,
  abstract     = {In a breast cancer series (n = 54), preoperative fine needle aspiration (FNA) was compared with biopsy at primary surgery as a source of material for the determination of progesterone receptor (PgR) content by enzyme immuno assay. The respective results manifested a strong correlation (r(s) = 0.82). The fact that PgR content was usually higher in FNA samples than in the corresponding biopsy samples and the finding that 11% of the tumours were PgR positive in FNA but PgR negative in the corresponding biopsy samples suggest a greater proportion of malignant cells to be obtained with FNA than in surgical biopsy. In another breast cancer series (n = 50), corresponding comparisons for DNA flow cytometry showed concordance in ploidy status (diploid vs. non-diploid) in 84% of cases and a strong correlation in S-phase fraction values (r(s) = 0.70). At DNA image cytometry, concordant results (Auer I + II vs. Auer III + IV) were obtained in 87% of the cases. To sum up, FNA seems to be a useful sampling technique for PgR determination and DNA cytometry.},
  author       = {Fernö, Mårten and Baldetorp, Bo and Fallenius, Ghita and Idvall, Ingrid and Johansson, Ulla and Killander, Dick},
  issn         = {1651-226X},
  language     = {eng},
  number       = {S8},
  pages        = {19--25},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Preoperative fine needle aspiration from human breast cancer is a valuable sampling material for progesterone receptor and cytometric DNA analysis},
  url          = {http://dx.doi.org/10.3109/02841869609098517},
  volume       = {35},
  year         = {1996},
}