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Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men

Lindgren, M; Eckert, B; Stenberg, Georg LU and Agardh, Carl-David LU (1996) In Diabetic Medicine 13(3). p.218-225
Abstract
The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes... (More)
The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hypoglycaemia Cognitive Function
in
Diabetic Medicine
volume
13
issue
3
pages
218 - 225
publisher
Wiley-Blackwell
external identifiers
  • pmid:8689841
  • scopus:0029926688
ISSN
1464-5491
DOI
10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-D
language
English
LU publication?
yes
id
518f2bf6-f092-4818-80c1-ba0e77253cfa (old id 1110229)
date added to LUP
2008-07-25 15:56:19
date last changed
2017-01-29 04:01:59
@article{518f2bf6-f092-4818-80c1-ba0e77253cfa,
  abstract     = {The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast.},
  author       = {Lindgren, M and Eckert, B and Stenberg, Georg and Agardh, Carl-David},
  issn         = {1464-5491},
  keyword      = {Hypoglycaemia Cognitive Function},
  language     = {eng},
  number       = {3},
  pages        = {218--225},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men},
  url          = {http://dx.doi.org/10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-D},
  volume       = {13},
  year         = {1996},
}