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Survival in cohorts of asbestos cement workers and controls

Albin, Maria LU ; Horstmann, Vibeke LU ; Jakobsson, Kristina LU and Welinder, Hans LU (1996) In Occupational and Environmental Medicine 53(2). p.87-93
Abstract
OBJECTIVES: To measure the impact on survival of being exposed to asbestos cement dust. METHODS: Survival of 866 asbestos cement workers and 755 controls was studied with Cox's proportional hazards regression models with age as the basic time variable. The effect of cumulative exposure up to the age of 40 was investigated in an internal analysis of 635 asbestos cement workers who had dose estimates. RESULTS: The death risk was higher for the asbestos cement workers than for the controls with a hazard ratio (HR) of 1.15 (95% confidence interval was 1.00 to 1.31). The increased risk found seemed to be confined to the period 20-40 years from start of employment. The estimates of the cohort effect were almost unaffected by adjustment for... (More)
OBJECTIVES: To measure the impact on survival of being exposed to asbestos cement dust. METHODS: Survival of 866 asbestos cement workers and 755 controls was studied with Cox's proportional hazards regression models with age as the basic time variable. The effect of cumulative exposure up to the age of 40 was investigated in an internal analysis of 635 asbestos cement workers who had dose estimates. RESULTS: The death risk was higher for the asbestos cement workers than for the controls with a hazard ratio (HR) of 1.15 (95% confidence interval was 1.00 to 1.31). The increased risk found seemed to be confined to the period 20-40 years from start of employment. The estimates of the cohort effect were almost unaffected by adjustment for smoking habits. The estimates of the exposure effect rose with increasing dose (< 4 fibre-years/ml (f-y/ml): HR = 1.00, 4-9.9 f-y/ml: HR = 1.06, > or = 10 f-y/ml: HR = 1.35, for workers with at least five years of employment), and were higher when restricted only to deaths from malignant or non-malignant respiratory disease. However, none of the point estimates were significantly increased. Median age at death was two years lower in the high than in the low, exposure group. CONCLUSIONS: The results indicate that even a moderate asbestos exposure may shorten the median duration of life in an exposed population. Compared with the estimated effect on duration of life from ever being a smoker, that of ever being an asbestos cement worker was less, although that of having a high exposure was similar. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asbestos cement workers, survival, dose
in
Occupational and Environmental Medicine
volume
53
issue
2
pages
87 - 93
publisher
BMJ Publishing Group
external identifiers
  • pmid:8777456
  • scopus:0030025929
ISSN
1470-7926
language
English
LU publication?
yes
id
c282c3ff-b2e9-4eca-8ebe-eab09a364a1b (old id 1110248)
date added to LUP
2008-07-21 09:30:49
date last changed
2017-01-01 07:27:18
@article{c282c3ff-b2e9-4eca-8ebe-eab09a364a1b,
  abstract     = {OBJECTIVES: To measure the impact on survival of being exposed to asbestos cement dust. METHODS: Survival of 866 asbestos cement workers and 755 controls was studied with Cox's proportional hazards regression models with age as the basic time variable. The effect of cumulative exposure up to the age of 40 was investigated in an internal analysis of 635 asbestos cement workers who had dose estimates. RESULTS: The death risk was higher for the asbestos cement workers than for the controls with a hazard ratio (HR) of 1.15 (95% confidence interval was 1.00 to 1.31). The increased risk found seemed to be confined to the period 20-40 years from start of employment. The estimates of the cohort effect were almost unaffected by adjustment for smoking habits. The estimates of the exposure effect rose with increasing dose (&lt; 4 fibre-years/ml (f-y/ml): HR = 1.00, 4-9.9 f-y/ml: HR = 1.06, &gt; or = 10 f-y/ml: HR = 1.35, for workers with at least five years of employment), and were higher when restricted only to deaths from malignant or non-malignant respiratory disease. However, none of the point estimates were significantly increased. Median age at death was two years lower in the high than in the low, exposure group. CONCLUSIONS: The results indicate that even a moderate asbestos exposure may shorten the median duration of life in an exposed population. Compared with the estimated effect on duration of life from ever being a smoker, that of ever being an asbestos cement worker was less, although that of having a high exposure was similar.},
  author       = {Albin, Maria and Horstmann, Vibeke and Jakobsson, Kristina and Welinder, Hans},
  issn         = {1470-7926},
  keyword      = {asbestos cement workers,survival,dose},
  language     = {eng},
  number       = {2},
  pages        = {87--93},
  publisher    = {BMJ Publishing Group},
  series       = {Occupational and Environmental Medicine},
  title        = {Survival in cohorts of asbestos cement workers and controls},
  volume       = {53},
  year         = {1996},
}