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Thromboprophylaxis with a low molecular weight heparin (tinzaparin) in emergency abdominal surgery. A double-blind multicenter trial

Bergqvist, D; Flordal, P A; Friberg, B; Frisell, J; Hedberg, M; Ljungstrom, K G; Mätzsch, Thomas LU and Torngren, S (1996) In Vasa: European Journal of Vascular Medicine 25(2). p.156-160
Abstract
In this prospective randomized double-blind study the thromboprophylactic effect of postoperative low molecular weight heparin (tinzaparin) was compared with placebo in 80 patients undergoing emergency abdominal surgery. The fibrinogen uptake test was used but because of withdrawal of the labelled fibrinogen from the market the calculated number of patients was not reached. However, this is one of the few studies in emergency abdominal surgery we thought it important to report. The frequency of deep vein thrombosis was reduced with prophylaxis from 22% (95% conf. intervall 11-38%) to 8% (2-21%), a risk reduction of 65%, which is however not significant. Together with data from the few previously published studies it can be concluded that... (More)
In this prospective randomized double-blind study the thromboprophylactic effect of postoperative low molecular weight heparin (tinzaparin) was compared with placebo in 80 patients undergoing emergency abdominal surgery. The fibrinogen uptake test was used but because of withdrawal of the labelled fibrinogen from the market the calculated number of patients was not reached. However, this is one of the few studies in emergency abdominal surgery we thought it important to report. The frequency of deep vein thrombosis was reduced with prophylaxis from 22% (95% conf. intervall 11-38%) to 8% (2-21%), a risk reduction of 65%, which is however not significant. Together with data from the few previously published studies it can be concluded that patients undergoing emergency abdominal surgery seem to benefit from prophylaxis, which should be instituted either before operation or at latest 24 hours after. The exact prophylactic relation between pre- and post-operative start would, however, require a separate, randomized study. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vasa: European Journal of Vascular Medicine
volume
25
issue
2
pages
156 - 160
publisher
Hans Huber
external identifiers
  • pmid:8659218
  • scopus:0029976918
ISSN
0301-1526
language
English
LU publication?
yes
id
2fbceb9f-94e9-4d09-9507-bf0496fa0393 (old id 1110425)
date added to LUP
2008-07-22 08:21:21
date last changed
2017-10-22 03:51:54
@article{2fbceb9f-94e9-4d09-9507-bf0496fa0393,
  abstract     = {In this prospective randomized double-blind study the thromboprophylactic effect of postoperative low molecular weight heparin (tinzaparin) was compared with placebo in 80 patients undergoing emergency abdominal surgery. The fibrinogen uptake test was used but because of withdrawal of the labelled fibrinogen from the market the calculated number of patients was not reached. However, this is one of the few studies in emergency abdominal surgery we thought it important to report. The frequency of deep vein thrombosis was reduced with prophylaxis from 22% (95% conf. intervall 11-38%) to 8% (2-21%), a risk reduction of 65%, which is however not significant. Together with data from the few previously published studies it can be concluded that patients undergoing emergency abdominal surgery seem to benefit from prophylaxis, which should be instituted either before operation or at latest 24 hours after. The exact prophylactic relation between pre- and post-operative start would, however, require a separate, randomized study.},
  author       = {Bergqvist, D and Flordal, P A and Friberg, B and Frisell, J and Hedberg, M and Ljungstrom, K G and Mätzsch, Thomas and Torngren, S},
  issn         = {0301-1526},
  language     = {eng},
  number       = {2},
  pages        = {156--160},
  publisher    = {Hans Huber},
  series       = {Vasa: European Journal of Vascular Medicine},
  title        = {Thromboprophylaxis with a low molecular weight heparin (tinzaparin) in emergency abdominal surgery. A double-blind multicenter trial},
  volume       = {25},
  year         = {1996},
}