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Contact allergy to the active ingredients of Bioban P 1487

Gruvberger, Birgitta LU ; Bruze, Magnus LU and Zimerson, Erik LU (1996) In Contact Dermatitis 35(3). p.141-145
Abstract
Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it... (More)
Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bioban P 1487, CAS 2224-44-4, CAS 1854-23-5, allergic contact dermatitis, delayed hypersensitivity, 4, 4'-(2-ethyl-2-nitro-1, 3-propanediyl)-bis morpholine, high-performance liquid chromatography, metal working fluids, 4-(2-nitrobutyl)-morpholine, preservatives, occupational, engineering industry
in
Contact Dermatitis
volume
35
issue
3
pages
141 - 145
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:8930473
  • scopus:0029805649
ISSN
0105-1873
DOI
10.1111/j.1600-0536.1996.tb02331.x
language
English
LU publication?
yes
id
4305336b-635e-4032-ab4f-b24f4ed6bfdb (old id 1110433)
date added to LUP
2008-07-23 10:41:16
date last changed
2017-05-07 03:27:35
@article{4305336b-635e-4032-ab4f-b24f4ed6bfdb,
  abstract     = {Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten.},
  author       = {Gruvberger, Birgitta and Bruze, Magnus and Zimerson, Erik},
  issn         = {0105-1873},
  keyword      = {Bioban P 1487,CAS 2224-44-4,CAS 1854-23-5,allergic contact dermatitis,delayed hypersensitivity,4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine,high-performance liquid chromatography,metal working fluids,4-(2-nitrobutyl)-morpholine,preservatives,occupational,engineering industry},
  language     = {eng},
  number       = {3},
  pages        = {141--145},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact allergy to the active ingredients of Bioban P 1487},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.1996.tb02331.x},
  volume       = {35},
  year         = {1996},
}