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CT and MR imaging of the liver using liver-specific contrast media. A comparative study in a tumour model

Leander, Peter LU ; Månsson, S; Ege, T and Besjakov, Jack LU (1996) In Acta Radiologica 37(3 Pt 1). p.242-249
Abstract
PURPOSE: A new type of liposomal liver-specific contrast medium (CM) in CT was studied, and the results were compared with those obtained with Mn-DPDP, a paramagnetic hepatobiliary CM, in MR imaging. The contrasts of normal liver tissue to tumorous tissue and the importance of the CM for tumour detection in the 2 modalities were studied in a rabbit tumour model. CT and T1-weighted pre- and postcontrast and T2-weighted MR images precontrast were obtained. MATERIAL, METHODS AND RESULTS: Compared to precontrast images, significantly higher contrasts of normal liver tissue to tumorous tissue were obtained after CM administration in both CT and MR examinations. At radiologic evaluation, significantly more tumours were detected after CM... (More)
PURPOSE: A new type of liposomal liver-specific contrast medium (CM) in CT was studied, and the results were compared with those obtained with Mn-DPDP, a paramagnetic hepatobiliary CM, in MR imaging. The contrasts of normal liver tissue to tumorous tissue and the importance of the CM for tumour detection in the 2 modalities were studied in a rabbit tumour model. CT and T1-weighted pre- and postcontrast and T2-weighted MR images precontrast were obtained. MATERIAL, METHODS AND RESULTS: Compared to precontrast images, significantly higher contrasts of normal liver tissue to tumorous tissue were obtained after CM administration in both CT and MR examinations. At radiologic evaluation, significantly more tumours were detected after CM administration in CT and in T1-weighted MR images than in precontrast images in CT and T1-weighted MR. There were no significant differences in tumour detection frequency in MR studies including a T2-weighted pulse sequence, postcontrast CT, or postcontrast T1-weighted MR imaging. CONCLUSION: The use of liver-specific CM improves visualization of liver tumours in CT and T1-weighted MR imaging. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica
volume
37
issue
3 Pt 1
pages
242 - 249
publisher
John Wiley & Sons
external identifiers
  • pmid:8845249
  • scopus:0030136555
ISSN
1600-0455
language
English
LU publication?
yes
id
f7e197e1-6424-4a43-948c-db6d84ce734f (old id 1110566)
date added to LUP
2008-07-25 14:33:53
date last changed
2017-07-30 04:26:15
@article{f7e197e1-6424-4a43-948c-db6d84ce734f,
  abstract     = {PURPOSE: A new type of liposomal liver-specific contrast medium (CM) in CT was studied, and the results were compared with those obtained with Mn-DPDP, a paramagnetic hepatobiliary CM, in MR imaging. The contrasts of normal liver tissue to tumorous tissue and the importance of the CM for tumour detection in the 2 modalities were studied in a rabbit tumour model. CT and T1-weighted pre- and postcontrast and T2-weighted MR images precontrast were obtained. MATERIAL, METHODS AND RESULTS: Compared to precontrast images, significantly higher contrasts of normal liver tissue to tumorous tissue were obtained after CM administration in both CT and MR examinations. At radiologic evaluation, significantly more tumours were detected after CM administration in CT and in T1-weighted MR images than in precontrast images in CT and T1-weighted MR. There were no significant differences in tumour detection frequency in MR studies including a T2-weighted pulse sequence, postcontrast CT, or postcontrast T1-weighted MR imaging. CONCLUSION: The use of liver-specific CM improves visualization of liver tumours in CT and T1-weighted MR imaging.},
  author       = {Leander, Peter and Månsson, S and Ege, T and Besjakov, Jack},
  issn         = {1600-0455},
  language     = {eng},
  number       = {3 Pt 1},
  pages        = {242--249},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {CT and MR imaging of the liver using liver-specific contrast media. A comparative study in a tumour model},
  volume       = {37},
  year         = {1996},
}