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Micro-organization of olivocerebellar and corticonuclear connections of the paravermal cerebellum in the cat

Garwicz, Martin LU ; Apps, R and Trott, J R (1996) In European Journal of Neuroscience 8(12). p.2726-2738
Abstract
The olivocerebellar and corticonuclear connections of the forelimb area of the paravermal medial C3 zone were studied in the cat using a combined electrophysiological and fluorescent tracer technique. During an initial operation under barbiturate anaesthesia, lobules IV/V of the cerebellar anterior lobe were exposed and small injections of dextran amines tagged with rhodamine or fluorescein were made into areas selected from four different electrophysiologically defined parts of the zone. The inferior olive and the deep cerebellar nuclei were then scrutinized for retrogradely labelled cells and anterogradely labelled axon terminals respectively. The findings demonstrate a detailed topographical organization within the olivocerebellar... (More)
The olivocerebellar and corticonuclear connections of the forelimb area of the paravermal medial C3 zone were studied in the cat using a combined electrophysiological and fluorescent tracer technique. During an initial operation under barbiturate anaesthesia, lobules IV/V of the cerebellar anterior lobe were exposed and small injections of dextran amines tagged with rhodamine or fluorescein were made into areas selected from four different electrophysiologically defined parts of the zone. The inferior olive and the deep cerebellar nuclei were then scrutinized for retrogradely labelled cells and anterogradely labelled axon terminals respectively. The findings demonstrate a detailed topographical organization within the olivocerebellar projection to the medial C3 zone and provide some evidence for a topographical organization of its projection to nucleus interpositus anterior. Both projections are described at a level of resolution not previously attained in neuroanatomical studies and the results strongly support the notion of a micro-compartmentalization of cerebellar olivo-corticonuclear circuits. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inferior olive, fluorescent tracing, motor control
in
European Journal of Neuroscience
volume
8
issue
12
pages
2726 - 2738
publisher
Wiley-Blackwell
external identifiers
  • pmid:8996822
  • scopus:0030480216
ISSN
1460-9568
DOI
10.1111/j.1460-9568.1996.tb01567.x
language
English
LU publication?
yes
id
863d2edd-5a30-4278-92bb-fcfc03ecf13c (old id 1110595)
date added to LUP
2008-07-23 10:24:33
date last changed
2017-01-01 04:36:50
@article{863d2edd-5a30-4278-92bb-fcfc03ecf13c,
  abstract     = {The olivocerebellar and corticonuclear connections of the forelimb area of the paravermal medial C3 zone were studied in the cat using a combined electrophysiological and fluorescent tracer technique. During an initial operation under barbiturate anaesthesia, lobules IV/V of the cerebellar anterior lobe were exposed and small injections of dextran amines tagged with rhodamine or fluorescein were made into areas selected from four different electrophysiologically defined parts of the zone. The inferior olive and the deep cerebellar nuclei were then scrutinized for retrogradely labelled cells and anterogradely labelled axon terminals respectively. The findings demonstrate a detailed topographical organization within the olivocerebellar projection to the medial C3 zone and provide some evidence for a topographical organization of its projection to nucleus interpositus anterior. Both projections are described at a level of resolution not previously attained in neuroanatomical studies and the results strongly support the notion of a micro-compartmentalization of cerebellar olivo-corticonuclear circuits.},
  author       = {Garwicz, Martin and Apps, R and Trott, J R},
  issn         = {1460-9568},
  keyword      = {inferior olive,fluorescent tracing,motor control},
  language     = {eng},
  number       = {12},
  pages        = {2726--2738},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neuroscience},
  title        = {Micro-organization of olivocerebellar and corticonuclear connections of the paravermal cerebellum in the cat},
  url          = {http://dx.doi.org/10.1111/j.1460-9568.1996.tb01567.x},
  volume       = {8},
  year         = {1996},
}