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Neonatal chronic sympathectomy in normotensive rats affects pial arteries: enhanced stiffness and reduced capacity to dilate

Kåhrström, J; Hardebo, Jan Erik and Owman, Christer LU (1996) In Acta Physiologica Scandinavica 157(2). p.217-224
Abstract
The functional implication of previously shown effects on pial wall morphology by sympathectomy was tested. Following either ganglionic or pre-ganglionic denervation in 1-week-old rats the passive arterial compliance was reduced in basal cerebral arteries of 20-week-old normotensive, but not of hypertensive animals. The magnitude of the denervation induced stiffness was similar to the alteration seen in spontaneously hypertensive rats when compared with normotensive animals. No difference was seen between the two types of denervation. Following ganglionic sympathectomy in 1-week old normotensive rats-and examined 19 weeks later-the increase in cerebral blood flow (measured with the [14C]butanol sampling technique) induced by high arterial... (More)
The functional implication of previously shown effects on pial wall morphology by sympathectomy was tested. Following either ganglionic or pre-ganglionic denervation in 1-week-old rats the passive arterial compliance was reduced in basal cerebral arteries of 20-week-old normotensive, but not of hypertensive animals. The magnitude of the denervation induced stiffness was similar to the alteration seen in spontaneously hypertensive rats when compared with normotensive animals. No difference was seen between the two types of denervation. Following ganglionic sympathectomy in 1-week old normotensive rats-and examined 19 weeks later-the increase in cerebral blood flow (measured with the [14C]butanol sampling technique) induced by high arterial CO2 concentration was attenuated compared with control, whereas basal cerebral blood flow of 20-week-old animals was not different from control. The results indicate a long-term role by the sympathetic nerves not only on vessel wall composition, but also on the regulatory capacity of the cerebral circulation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arterial compliance, cerebral blood flow, sympathectomy, trophic effects
in
Acta Physiologica Scandinavica
volume
157
issue
2
pages
217 - 224
publisher
Wiley-Blackwell
external identifiers
  • pmid:8800362
  • scopus:0029890390
ISSN
0001-6772
DOI
10.1046/j.1365-201X.1996.d01-743.x
language
English
LU publication?
yes
id
3b26da67-3fb4-4939-95ff-6438219e6f6e (old id 1110669)
date added to LUP
2008-07-24 10:44:02
date last changed
2017-01-01 06:45:06
@article{3b26da67-3fb4-4939-95ff-6438219e6f6e,
  abstract     = {The functional implication of previously shown effects on pial wall morphology by sympathectomy was tested. Following either ganglionic or pre-ganglionic denervation in 1-week-old rats the passive arterial compliance was reduced in basal cerebral arteries of 20-week-old normotensive, but not of hypertensive animals. The magnitude of the denervation induced stiffness was similar to the alteration seen in spontaneously hypertensive rats when compared with normotensive animals. No difference was seen between the two types of denervation. Following ganglionic sympathectomy in 1-week old normotensive rats-and examined 19 weeks later-the increase in cerebral blood flow (measured with the [14C]butanol sampling technique) induced by high arterial CO2 concentration was attenuated compared with control, whereas basal cerebral blood flow of 20-week-old animals was not different from control. The results indicate a long-term role by the sympathetic nerves not only on vessel wall composition, but also on the regulatory capacity of the cerebral circulation.},
  author       = {Kåhrström, J and Hardebo, Jan Erik and Owman, Christer},
  issn         = {0001-6772},
  keyword      = {arterial compliance,cerebral blood flow,sympathectomy,trophic effects},
  language     = {eng},
  number       = {2},
  pages        = {217--224},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {Neonatal chronic sympathectomy in normotensive rats affects pial arteries: enhanced stiffness and reduced capacity to dilate},
  url          = {http://dx.doi.org/10.1046/j.1365-201X.1996.d01-743.x},
  volume       = {157},
  year         = {1996},
}