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The effect of reduced glomerular filtration rate on plasma total homocysteine concentration

Arnadottir, M; Hultberg, Björn LU ; Nilsson-Ehle, Peter LU and Thysell, Hans LU (1996) In Scandinavian Journal of Clinical & Laboratory Investigation 56(1). p.41-46
Abstract
The concentration of homocysteine in plasma has been shown to be increased in renal failure, possibly contributing to the accelerated atherosclerosis observed in uraemic patients. The aim of the present study was to document the relationship between plasma total homocysteine (tHcy) concentrations and glomerular filtration rates (GFR) in highly selected patients, with renal function ranging from normal to dialysis dependency. GFR was defined as the plasma clearance of iohexol; a more accurate method than the creatinine-based estimations applied in previous studies. Plasma tHcy concentrations were highly correlated to GFR (r = -0.70, p < 0.0001) and were significantly increased already in moderate renal failure. According to a multiple... (More)
The concentration of homocysteine in plasma has been shown to be increased in renal failure, possibly contributing to the accelerated atherosclerosis observed in uraemic patients. The aim of the present study was to document the relationship between plasma total homocysteine (tHcy) concentrations and glomerular filtration rates (GFR) in highly selected patients, with renal function ranging from normal to dialysis dependency. GFR was defined as the plasma clearance of iohexol; a more accurate method than the creatinine-based estimations applied in previous studies. Plasma tHcy concentrations were highly correlated to GFR (r = -0.70, p < 0.0001) and were significantly increased already in moderate renal failure. According to a multiple regression analysis, GFR and red cell folate concentrations independently predicted plasma tHcy concentrations, whereas those of serum creatinine, plasma pyridoxal-5-phosphate, urine albumin and urine alpha-1-microglobulin (a marker of tubular damage) did not. Thus, GFR seems to be a better determinant of plasma tHcy concentration than serum creatinine concentration. Plasma total cysteine and total cysteinylglycine concentrations followed the same pattern as those of tHcy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha-l-microglobulin, cysteine, folate, hyperhomocysteinaemia, pyri-doxal-5-phosphate, renal failure
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
56
issue
1
pages
41 - 46
publisher
Informa Healthcare
external identifiers
  • pmid:8850171
  • scopus:0030022202
ISSN
1502-7686
DOI
10.3109/00365519609088586
language
English
LU publication?
yes
id
b2a6af13-ded4-4bb2-8378-9a814bb59485 (old id 1110734)
date added to LUP
2008-07-21 10:31:46
date last changed
2017-09-17 08:04:15
@article{b2a6af13-ded4-4bb2-8378-9a814bb59485,
  abstract     = {The concentration of homocysteine in plasma has been shown to be increased in renal failure, possibly contributing to the accelerated atherosclerosis observed in uraemic patients. The aim of the present study was to document the relationship between plasma total homocysteine (tHcy) concentrations and glomerular filtration rates (GFR) in highly selected patients, with renal function ranging from normal to dialysis dependency. GFR was defined as the plasma clearance of iohexol; a more accurate method than the creatinine-based estimations applied in previous studies. Plasma tHcy concentrations were highly correlated to GFR (r = -0.70, p &lt; 0.0001) and were significantly increased already in moderate renal failure. According to a multiple regression analysis, GFR and red cell folate concentrations independently predicted plasma tHcy concentrations, whereas those of serum creatinine, plasma pyridoxal-5-phosphate, urine albumin and urine alpha-1-microglobulin (a marker of tubular damage) did not. Thus, GFR seems to be a better determinant of plasma tHcy concentration than serum creatinine concentration. Plasma total cysteine and total cysteinylglycine concentrations followed the same pattern as those of tHcy.},
  author       = {Arnadottir, M and Hultberg, Björn and Nilsson-Ehle, Peter and Thysell, Hans},
  issn         = {1502-7686},
  keyword      = {alpha-l-microglobulin,cysteine,folate,hyperhomocysteinaemia,pyri-doxal-5-phosphate,renal failure},
  language     = {eng},
  number       = {1},
  pages        = {41--46},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {The effect of reduced glomerular filtration rate on plasma total homocysteine concentration},
  url          = {http://dx.doi.org/10.3109/00365519609088586},
  volume       = {56},
  year         = {1996},
}