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Frequent occurrence of a variant O1 gene at the blood group ABO locus

Olsson, Martin L LU and Chester, Alan LU (1996) In Vox Sanguinis 70(1). p.26-30
Abstract
Blood group ABO polymorphism was analysed in genomic DNA isolated from 150 blood donors by restriction endonuclease digestion of three polymerase chain reaction-amplified exons in the ABO genes and by sequencing of randomly selected samples. An anomalous O1 allele first described in a cancer cell line is now shown to account for approximately 40% of the O alleles described to date. This is 10 times more frequent than the only other known variant O allele (O2). This variant O1 allele has at least seven point mutations when compared to the consensus gene, in addition to the deletion characterising the normal O1 allele.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vox Sanguinis
volume
70
issue
1
pages
26 - 30
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:8928487
  • scopus:0030051593
ISSN
1423-0410
language
English
LU publication?
yes
id
df1030d9-756d-48aa-9872-8b76cd4982d3 (old id 1110851)
date added to LUP
2008-07-28 10:48:46
date last changed
2017-08-20 04:30:46
@article{df1030d9-756d-48aa-9872-8b76cd4982d3,
  abstract     = {Blood group ABO polymorphism was analysed in genomic DNA isolated from 150 blood donors by restriction endonuclease digestion of three polymerase chain reaction-amplified exons in the ABO genes and by sequencing of randomly selected samples. An anomalous O1 allele first described in a cancer cell line is now shown to account for approximately 40% of the O alleles described to date. This is 10 times more frequent than the only other known variant O allele (O2). This variant O1 allele has at least seven point mutations when compared to the consensus gene, in addition to the deletion characterising the normal O1 allele.},
  author       = {Olsson, Martin L and Chester, Alan},
  issn         = {1423-0410},
  language     = {eng},
  number       = {1},
  pages        = {26--30},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Vox Sanguinis},
  title        = {Frequent occurrence of a variant O1 gene at the blood group ABO locus},
  volume       = {70},
  year         = {1996},
}