Advanced

Acute glomerulonephritis, Henoch-Schonlein purpura and dental amalgam in Swedish children: a case-control study

Herrstrom, Per; Hogstedt, Benkt; Aronson, Stefan; Holmen, Anders and Råstam, Lennart LU (1996) In Science of the Total Environment 191(3). p.277-282
Abstract
The issue of adverse health effects from dental amalgam and the concurrent low-dose exposure to inorganic mercury have been scrutinized by several Swedish expert groups during the past years. Only rarely have amalgam fillings in children been related to health effects. Experimental studies in genetically disposed animals have shown that low doses of inorganic mercury can induce autoimmune glomerulonephritis. The present case-control study included 31 children with acute glomerulonephritis and 33 with Henoch-Schonlein purpura retrieved from an in-patient register for the period 1973-1992 at the county hospital in Halmstad, Sweden. The median age was 10 and 9 years, respectively, for the two diagnostic groups. Dental clinics reported amalgam... (More)
The issue of adverse health effects from dental amalgam and the concurrent low-dose exposure to inorganic mercury have been scrutinized by several Swedish expert groups during the past years. Only rarely have amalgam fillings in children been related to health effects. Experimental studies in genetically disposed animals have shown that low doses of inorganic mercury can induce autoimmune glomerulonephritis. The present case-control study included 31 children with acute glomerulonephritis and 33 with Henoch-Schonlein purpura retrieved from an in-patient register for the period 1973-1992 at the county hospital in Halmstad, Sweden. The median age was 10 and 9 years, respectively, for the two diagnostic groups. Dental clinics reported amalgam burden of the patients during the year before the date of diagnosis. Corresponding data were obtained for three randomly selected controls for each case, drawn from the case records of the same dental clinics, with matching for age and sex. Odds ratios (95% confidence interval) were 1.42 (0.49, 4.11) for Henoch-Schonlein purpura, 0.59 (0.25, 1.38) for acute glomerulonephritis and 0.84 (0.40, 1.75) for both diseases combined. The results of this study did not indicate increased disease risk in relation to amalgam burden. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dental amalgam, Children, Acute glomerulonephritis, Case-control study, Henoch-Schönlein purpura, Mercury
in
Science of the Total Environment
volume
191
issue
3
pages
277 - 282
publisher
Elsevier
external identifiers
  • pmid:8931347
  • scopus:0030598351
ISSN
1879-1026
DOI
10.1016/S0048-9697(96)05270-9
language
English
LU publication?
yes
id
ca23850e-805e-427b-8e42-286ac065b767 (old id 1110885)
date added to LUP
2008-07-24 08:21:57
date last changed
2017-01-22 03:34:11
@article{ca23850e-805e-427b-8e42-286ac065b767,
  abstract     = {The issue of adverse health effects from dental amalgam and the concurrent low-dose exposure to inorganic mercury have been scrutinized by several Swedish expert groups during the past years. Only rarely have amalgam fillings in children been related to health effects. Experimental studies in genetically disposed animals have shown that low doses of inorganic mercury can induce autoimmune glomerulonephritis. The present case-control study included 31 children with acute glomerulonephritis and 33 with Henoch-Schonlein purpura retrieved from an in-patient register for the period 1973-1992 at the county hospital in Halmstad, Sweden. The median age was 10 and 9 years, respectively, for the two diagnostic groups. Dental clinics reported amalgam burden of the patients during the year before the date of diagnosis. Corresponding data were obtained for three randomly selected controls for each case, drawn from the case records of the same dental clinics, with matching for age and sex. Odds ratios (95% confidence interval) were 1.42 (0.49, 4.11) for Henoch-Schonlein purpura, 0.59 (0.25, 1.38) for acute glomerulonephritis and 0.84 (0.40, 1.75) for both diseases combined. The results of this study did not indicate increased disease risk in relation to amalgam burden.},
  author       = {Herrstrom, Per and Hogstedt, Benkt and Aronson, Stefan and Holmen, Anders and Råstam, Lennart},
  issn         = {1879-1026},
  keyword      = {Dental amalgam,Children,Acute glomerulonephritis,Case-control study,Henoch-Schönlein purpura,Mercury},
  language     = {eng},
  number       = {3},
  pages        = {277--282},
  publisher    = {Elsevier},
  series       = {Science of the Total Environment},
  title        = {Acute glomerulonephritis, Henoch-Schonlein purpura and dental amalgam in Swedish children: a case-control study},
  url          = {http://dx.doi.org/10.1016/S0048-9697(96)05270-9},
  volume       = {191},
  year         = {1996},
}