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Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study

Råstam, Lennart LU ; Lindberg, Gunnar; Folsom, Aaron R; Burke, Gregory L; Nilsson-Ehle, Peter LU and Lundblad, Arne (1996) In International Journal of Epidemiology 25(5). p.953-958
Abstract
BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated. METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis. RESULTS: The mean (SD) serum sialic acid... (More)
BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated. METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis. RESULTS: The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70. CONCLUSION: The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glycoproteins, atherosclerosis, B-mode ultrasound, sialic acid
in
International Journal of Epidemiology
volume
25
issue
5
pages
953 - 958
publisher
Oxford University Press
external identifiers
  • pmid:8921480
  • scopus:0029910126
ISSN
1464-3685
DOI
10.1093/ije/25.5.953
language
English
LU publication?
yes
id
14f03688-46eb-4438-b882-4b83f4c3ae02 (old id 1110890)
date added to LUP
2008-07-29 09:43:27
date last changed
2017-08-06 03:44:46
@article{14f03688-46eb-4438-b882-4b83f4c3ae02,
  abstract     = {BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated. METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis. RESULTS: The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70. CONCLUSION: The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved.},
  author       = {Råstam, Lennart and Lindberg, Gunnar and Folsom, Aaron R and Burke, Gregory L and Nilsson-Ehle, Peter and Lundblad, Arne},
  issn         = {1464-3685},
  keyword      = {glycoproteins,atherosclerosis,B-mode ultrasound,sialic acid},
  language     = {eng},
  number       = {5},
  pages        = {953--958},
  publisher    = {Oxford University Press},
  series       = {International Journal of Epidemiology},
  title        = {Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study},
  url          = {http://dx.doi.org/10.1093/ije/25.5.953},
  volume       = {25},
  year         = {1996},
}