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Cell survival after Auger electron emission from stable intracellular indium exposed to monochromatic synchrotron radiation

Jonsson, Ann-Charlotte; Jönsson, Bo-Anders LU ; Strand, Sven-Erik LU ; Grafström, Gustav LU and Spanne, Per (1996) In Acta Oncologica 35(7). p.947-952
Abstract
The biological effect of Auger electrons emitted from indium in V79 cells was investigated. K-shell vacancies were induced by synchrotron x-rays. Two energies, 100 eV above and below the K-edge of indium, were used. The cell survival for controls was similar to that which has been reported by others, with D37 = 4.4 Gy. Indium-oxine-labelled cells exhibited a survival clearly below that of the controls, D37 = 3.2 Gy, but no significant difference in survival between irradiations above and below the K-edge could be observed. The explanation is, inter alia, that the number of photons interacting with indium atoms incorporated into the cell, is small compared with the number of photons interacting with other atoms in the cell. The toxicity of... (More)
The biological effect of Auger electrons emitted from indium in V79 cells was investigated. K-shell vacancies were induced by synchrotron x-rays. Two energies, 100 eV above and below the K-edge of indium, were used. The cell survival for controls was similar to that which has been reported by others, with D37 = 4.4 Gy. Indium-oxine-labelled cells exhibited a survival clearly below that of the controls, D37 = 3.2 Gy, but no significant difference in survival between irradiations above and below the K-edge could be observed. The explanation is, inter alia, that the number of photons interacting with indium atoms incorporated into the cell, is small compared with the number of photons interacting with other atoms in the cell. The toxicity of indium oxine made it impossible to incorporate a sufficient number of indium atoms into the cells to observe a difference in this study. However, monoenergetic irradiation above and below the K-edge, provides a technique for the investigation of basic biological effects of Auger processes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
35
issue
7
pages
947 - 952
publisher
Taylor & Francis
external identifiers
  • scopus:0030449296
ISSN
1651-226X
DOI
10.3109/02841869609104050
language
English
LU publication?
yes
id
90c3d0ff-90a2-491c-9c96-f27712f0e25b (old id 1111175)
date added to LUP
2008-08-28 11:02:34
date last changed
2017-01-01 06:37:59
@article{90c3d0ff-90a2-491c-9c96-f27712f0e25b,
  abstract     = {The biological effect of Auger electrons emitted from indium in V79 cells was investigated. K-shell vacancies were induced by synchrotron x-rays. Two energies, 100 eV above and below the K-edge of indium, were used. The cell survival for controls was similar to that which has been reported by others, with D37 = 4.4 Gy. Indium-oxine-labelled cells exhibited a survival clearly below that of the controls, D37 = 3.2 Gy, but no significant difference in survival between irradiations above and below the K-edge could be observed. The explanation is, inter alia, that the number of photons interacting with indium atoms incorporated into the cell, is small compared with the number of photons interacting with other atoms in the cell. The toxicity of indium oxine made it impossible to incorporate a sufficient number of indium atoms into the cells to observe a difference in this study. However, monoenergetic irradiation above and below the K-edge, provides a technique for the investigation of basic biological effects of Auger processes.},
  author       = {Jonsson, Ann-Charlotte and Jönsson, Bo-Anders and Strand, Sven-Erik and Grafström, Gustav and Spanne, Per},
  issn         = {1651-226X},
  language     = {eng},
  number       = {7},
  pages        = {947--952},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Cell survival after Auger electron emission from stable intracellular indium exposed to monochromatic synchrotron radiation},
  url          = {http://dx.doi.org/10.3109/02841869609104050},
  volume       = {35},
  year         = {1996},
}