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Lack of association between cystopathy and progression of diabetic nephropathy in insulin-dependent diabetes mellitus

Torffvit, Ole LU ; Agardh, Carl-David LU and Mattiasson, Anders LU (1997) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 31(4). p.365-369
Abstract
Whether an association exists between cystopathy and progression of diabetic nephropathy has never been clarified. The aim of the present study was to measure the degree of cystopathy in relation to the rate of progression of diabetic nephropathy. To that end, 17 insulin-dependent diabetic patients with diabetic nephropathy but without voiding symptoms were investigated urodynamically. The median age of the patients was 45 years (range 27-67 years), diabetes duration 23 years (range 14-44 years) and the serum creatinine level was 162 mumol/L (median, range 65-449 mumol/L) at the time of the study. The progression rate of diabetic nephropathy was analysed retrospectively by measuring changes in yearly mean values of Log10 serum creatinine... (More)
Whether an association exists between cystopathy and progression of diabetic nephropathy has never been clarified. The aim of the present study was to measure the degree of cystopathy in relation to the rate of progression of diabetic nephropathy. To that end, 17 insulin-dependent diabetic patients with diabetic nephropathy but without voiding symptoms were investigated urodynamically. The median age of the patients was 45 years (range 27-67 years), diabetes duration 23 years (range 14-44 years) and the serum creatinine level was 162 mumol/L (median, range 65-449 mumol/L) at the time of the study. The progression rate of diabetic nephropathy was analysed retrospectively by measuring changes in yearly mean values of Log10 serum creatinine for a period of 13 years (3-15 years) before the investigation. The progression rate was 0.028 mumol/L/year (median). Patients with a progression rate above and below the median rate were considered to be rapid (n = 8) and slow (n = 9) progressors, respectively. More women than men had a rapid progression rate of nephropathy. Rapid progressors were found to have smaller volume or residual urine (90 vs 165 ml; p < 0.05), larger volume voided (440 vs 270 ml; p < 0.05), lower opening pressure (18 vs 48 cm H2O; p < 0.05) and lower pressure at maximum flow (37 vs 64 cm H2O; p < 0.05) compared to slow progressors. However, these variables were not related to the progression rate of nephropathy (MANOVA). Furthermore, these results should be interpreted with caution because of the natural gender differences in pressure conditions. In conclusion, rapid progression of diabetic nephropathy does not seem to be associated with dysfunction of the urinary bladder measured with cystometry and pressure flow. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autonomic neuropathy, diabetic nephropathy, diabetes mellitus, urodynamic investigation
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
31
issue
4
pages
365 - 369
publisher
Taylor & Francis
external identifiers
  • pmid:9290167
ISSN
0036-5599
DOI
10.3109/00365599709030621
language
English
LU publication?
yes
id
b2217aca-b820-4cdb-9894-321854481ea2 (old id 1111198)
date added to LUP
2008-07-16 17:07:33
date last changed
2017-02-22 11:44:26
@article{b2217aca-b820-4cdb-9894-321854481ea2,
  abstract     = {Whether an association exists between cystopathy and progression of diabetic nephropathy has never been clarified. The aim of the present study was to measure the degree of cystopathy in relation to the rate of progression of diabetic nephropathy. To that end, 17 insulin-dependent diabetic patients with diabetic nephropathy but without voiding symptoms were investigated urodynamically. The median age of the patients was 45 years (range 27-67 years), diabetes duration 23 years (range 14-44 years) and the serum creatinine level was 162 mumol/L (median, range 65-449 mumol/L) at the time of the study. The progression rate of diabetic nephropathy was analysed retrospectively by measuring changes in yearly mean values of Log10 serum creatinine for a period of 13 years (3-15 years) before the investigation. The progression rate was 0.028 mumol/L/year (median). Patients with a progression rate above and below the median rate were considered to be rapid (n = 8) and slow (n = 9) progressors, respectively. More women than men had a rapid progression rate of nephropathy. Rapid progressors were found to have smaller volume or residual urine (90 vs 165 ml; p &lt; 0.05), larger volume voided (440 vs 270 ml; p &lt; 0.05), lower opening pressure (18 vs 48 cm H2O; p &lt; 0.05) and lower pressure at maximum flow (37 vs 64 cm H2O; p &lt; 0.05) compared to slow progressors. However, these variables were not related to the progression rate of nephropathy (MANOVA). Furthermore, these results should be interpreted with caution because of the natural gender differences in pressure conditions. In conclusion, rapid progression of diabetic nephropathy does not seem to be associated with dysfunction of the urinary bladder measured with cystometry and pressure flow.},
  author       = {Torffvit, Ole and Agardh, Carl-David and Mattiasson, Anders},
  issn         = {0036-5599},
  keyword      = {autonomic neuropathy,diabetic nephropathy,diabetes mellitus,urodynamic investigation},
  language     = {eng},
  number       = {4},
  pages        = {365--369},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Lack of association between cystopathy and progression of diabetic nephropathy in insulin-dependent diabetes mellitus},
  url          = {http://dx.doi.org/10.3109/00365599709030621},
  volume       = {31},
  year         = {1997},
}