Chronic non-A, non-B, non-C hepatitis: is hepatitis G/GBV-C involved?
(1997) In Scandinavian Journal of Gastroenterology 32(10). p.1046-1051- Abstract
- BACKGROUND: Hepatitis G virus/GBV-C is a recently discovered virus, and its relevance in chronic hepatitis is still debated. METHODS: We have previously described 127 long-term-studied and well-characterized patients with chronic non-A, non-B hepatitis (NANBH). Ninety-one (71.7%) were positive for hepatitis C virus antibodies (anti-HCV) in a first-generation anti-HCV enzyme-linked immunosorbent assay (ELISA). We now reanalyzed the same group of patients and added a third-generation anti-HCV ELISA and recombinant immunoblot assay and, in negative patients, also polymerase chain reactions for hepatitis C virus RNA, hepatitis GBV-C RNA, and hepatitis B virus DNA. Additional tests for autoimmune hepatitis types 2 and 3 were also included.... (More)
- BACKGROUND: Hepatitis G virus/GBV-C is a recently discovered virus, and its relevance in chronic hepatitis is still debated. METHODS: We have previously described 127 long-term-studied and well-characterized patients with chronic non-A, non-B hepatitis (NANBH). Ninety-one (71.7%) were positive for hepatitis C virus antibodies (anti-HCV) in a first-generation anti-HCV enzyme-linked immunosorbent assay (ELISA). We now reanalyzed the same group of patients and added a third-generation anti-HCV ELISA and recombinant immunoblot assay and, in negative patients, also polymerase chain reactions for hepatitis C virus RNA, hepatitis GBV-C RNA, and hepatitis B virus DNA. Additional tests for autoimmune hepatitis types 2 and 3 were also included. RESULTS: Anti-HCV were detected in 114 of the 123 evaluable patients (92.7%). Of the remaining nine anti-HCV-negative patients one had misdiagnosed primary biliary cirrhosis, and two had autoimmune hepatitis type 3. None of the anti-HCV-negative patients were hepatitis GBV-C RNA-, HCV RNA-, or HBV DNA-positive. Thus, 114 of 120 NANBH patients (95.0%) had chronic hepatitis C. None of the remaining six patients had received blood transfusions or was a drug addict, and two of them were successfully treated with steroids. CONCLUSIONS: Hepatitis G/GBV-C as a single cause of chronic non-A, non-B hepatitis is uncommon, and in all patients with parenteral risk factors hepatitis C was detected. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111266
- author
- Wejstal, R ; Norkrans, G and Widell, Anders LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chronic hepatitis, hepatitis C, hepatitis G, non-A, non-B hepatitis
- in
- Scandinavian Journal of Gastroenterology
- volume
- 32
- issue
- 10
- pages
- 1046 - 1051
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:9361179
- scopus:0030847518
- ISSN
- 1502-7708
- DOI
- 10.3109/00365529709011223
- language
- English
- LU publication?
- yes
- id
- f62438d9-f634-47d6-81e7-8e59341d9eb5 (old id 1111266)
- date added to LUP
- 2016-04-01 17:05:21
- date last changed
- 2022-01-29 00:17:35
@article{f62438d9-f634-47d6-81e7-8e59341d9eb5,
abstract = {{BACKGROUND: Hepatitis G virus/GBV-C is a recently discovered virus, and its relevance in chronic hepatitis is still debated. METHODS: We have previously described 127 long-term-studied and well-characterized patients with chronic non-A, non-B hepatitis (NANBH). Ninety-one (71.7%) were positive for hepatitis C virus antibodies (anti-HCV) in a first-generation anti-HCV enzyme-linked immunosorbent assay (ELISA). We now reanalyzed the same group of patients and added a third-generation anti-HCV ELISA and recombinant immunoblot assay and, in negative patients, also polymerase chain reactions for hepatitis C virus RNA, hepatitis GBV-C RNA, and hepatitis B virus DNA. Additional tests for autoimmune hepatitis types 2 and 3 were also included. RESULTS: Anti-HCV were detected in 114 of the 123 evaluable patients (92.7%). Of the remaining nine anti-HCV-negative patients one had misdiagnosed primary biliary cirrhosis, and two had autoimmune hepatitis type 3. None of the anti-HCV-negative patients were hepatitis GBV-C RNA-, HCV RNA-, or HBV DNA-positive. Thus, 114 of 120 NANBH patients (95.0%) had chronic hepatitis C. None of the remaining six patients had received blood transfusions or was a drug addict, and two of them were successfully treated with steroids. CONCLUSIONS: Hepatitis G/GBV-C as a single cause of chronic non-A, non-B hepatitis is uncommon, and in all patients with parenteral risk factors hepatitis C was detected.}},
author = {{Wejstal, R and Norkrans, G and Widell, Anders}},
issn = {{1502-7708}},
keywords = {{Chronic hepatitis; hepatitis C; hepatitis G; non-A; non-B hepatitis}},
language = {{eng}},
number = {{10}},
pages = {{1046--1051}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Chronic non-A, non-B, non-C hepatitis: is hepatitis G/GBV-C involved?}},
url = {{http://dx.doi.org/10.3109/00365529709011223}},
doi = {{10.3109/00365529709011223}},
volume = {{32}},
year = {{1997}},
}