Advanced

Early prediction of treatment outcome in head and neck cancer with 2-18FDG PET

Brun, Eva LU ; Ohlsson, Tomas G LU ; Erlandsson, Kjell; Kjellén, Elisabeth LU ; Sandell, Anders LU ; Tennvall, Jan LU ; Wennerberg, Johan and Strand, Sven-Erik LU (1997) In Acta Oncologica 36(7). p.741-747
Abstract
The development of alternative treatment regimens in clinical oncology has increased the need for early prediction of cancer therapy outcome. The aim of this study was, early in the treatment phase, to identify patients with advanced head and neck cancer, responding or not responding to initiated therapy. The tumour metabolic rate of glucose (MRgl) examined by 2-18FDG-PET was determined in 17 patients before and after the first weeks of either radiotherapy (16-35 Gy) or one course of combination chemotherapy. Metabolic values uptake values normalized to plasma activity integrals--were correlated to loco-regional outcome, as evaluated 5-6 weeks after completion of treatment. Initial low tumour MRgl (<20 micromol/min/100 g tissue), in... (More)
The development of alternative treatment regimens in clinical oncology has increased the need for early prediction of cancer therapy outcome. The aim of this study was, early in the treatment phase, to identify patients with advanced head and neck cancer, responding or not responding to initiated therapy. The tumour metabolic rate of glucose (MRgl) examined by 2-18FDG-PET was determined in 17 patients before and after the first weeks of either radiotherapy (16-35 Gy) or one course of combination chemotherapy. Metabolic values uptake values normalized to plasma activity integrals--were correlated to loco-regional outcome, as evaluated 5-6 weeks after completion of treatment. Initial low tumour MRgl (<20 micromol/min/100 g tissue), in primary lesions or regional metastases, predicted a local complete response. When a high initial tumour MRgl was found, the magnitude of the reduction of MRgl in the second PET examination might be an adjunct in predicting local tumour response. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
36
issue
7
pages
741 - 747
publisher
Taylor & Francis
external identifiers
  • pmid:9490094
  • scopus:0031408018
ISSN
1651-226X
DOI
10.3109/02841869709001348
language
English
LU publication?
yes
id
6a8eb3f8-4f08-498d-8f75-66238c946232 (old id 1111504)
date added to LUP
2008-07-17 14:38:02
date last changed
2017-01-01 06:42:48
@article{6a8eb3f8-4f08-498d-8f75-66238c946232,
  abstract     = {The development of alternative treatment regimens in clinical oncology has increased the need for early prediction of cancer therapy outcome. The aim of this study was, early in the treatment phase, to identify patients with advanced head and neck cancer, responding or not responding to initiated therapy. The tumour metabolic rate of glucose (MRgl) examined by 2-18FDG-PET was determined in 17 patients before and after the first weeks of either radiotherapy (16-35 Gy) or one course of combination chemotherapy. Metabolic values uptake values normalized to plasma activity integrals--were correlated to loco-regional outcome, as evaluated 5-6 weeks after completion of treatment. Initial low tumour MRgl (&lt;20 micromol/min/100 g tissue), in primary lesions or regional metastases, predicted a local complete response. When a high initial tumour MRgl was found, the magnitude of the reduction of MRgl in the second PET examination might be an adjunct in predicting local tumour response.},
  author       = {Brun, Eva and Ohlsson, Tomas G and Erlandsson, Kjell and Kjellén, Elisabeth and Sandell, Anders and Tennvall, Jan and Wennerberg, Johan and Strand, Sven-Erik},
  issn         = {1651-226X},
  language     = {eng},
  number       = {7},
  pages        = {741--747},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Early prediction of treatment outcome in head and neck cancer with 2-18FDG PET},
  url          = {http://dx.doi.org/10.3109/02841869709001348},
  volume       = {36},
  year         = {1997},
}