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Effect of propofol on isolated human omental arteries and veins

Wallerstedt, S M and Bodelsson, Mikael LU (1997) In British Journal of Anaesthesia 78(3). p.296-300
Abstract
To elucidate the effect and mode of action of propofol on human vascular smooth muscle tension, we have investigated the effect of propofol alone and the effect of propofol on contractions induced by U46619, KCl and caffeine on isolated human omental vessels. Propofol 10(-3) mol litre-1 induced contractions in both arteries and veins attenuated the contraction elicited by U46619, KCl and caffeine in a concentration-dependent manner. The threshold concentrations for the effect of propofol in the artery were: 10(-5) mol litre-1 (U46619, caffeine) and 10(-4) mol litre-1 (KCl); and in the vein, 10(-5) mol litre-1 (U46619) and 10(-4) mol litre-1 (KCl, caffeine). We conclude that propofol at lower concentrations appeared to primarily attenuate... (More)
To elucidate the effect and mode of action of propofol on human vascular smooth muscle tension, we have investigated the effect of propofol alone and the effect of propofol on contractions induced by U46619, KCl and caffeine on isolated human omental vessels. Propofol 10(-3) mol litre-1 induced contractions in both arteries and veins attenuated the contraction elicited by U46619, KCl and caffeine in a concentration-dependent manner. The threshold concentrations for the effect of propofol in the artery were: 10(-5) mol litre-1 (U46619, caffeine) and 10(-4) mol litre-1 (KCl); and in the vein, 10(-5) mol litre-1 (U46619) and 10(-4) mol litre-1 (KCl, caffeine). We conclude that propofol at lower concentrations appeared to primarily attenuate contraction involving release of cellularly sequestered calcium. At higher concentrations (> 10(-4.5) mol litre-1), propofol appeared to affect contraction involving extracellular or intracellular calcium fluxes similarly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Anaesthesia
volume
78
issue
3
pages
296 - 300
publisher
Macmillan
external identifiers
  • pmid:9135309
  • scopus:0031038788
ISSN
1471-6771
language
English
LU publication?
yes
id
71fb1041-47db-4893-a42a-111c1ec312c0 (old id 1111524)
alternative location
http://bja.oxfordjournals.org/cgi/reprint/78/3/296
date added to LUP
2008-07-17 15:40:00
date last changed
2017-06-18 03:44:39
@article{71fb1041-47db-4893-a42a-111c1ec312c0,
  abstract     = {To elucidate the effect and mode of action of propofol on human vascular smooth muscle tension, we have investigated the effect of propofol alone and the effect of propofol on contractions induced by U46619, KCl and caffeine on isolated human omental vessels. Propofol 10(-3) mol litre-1 induced contractions in both arteries and veins attenuated the contraction elicited by U46619, KCl and caffeine in a concentration-dependent manner. The threshold concentrations for the effect of propofol in the artery were: 10(-5) mol litre-1 (U46619, caffeine) and 10(-4) mol litre-1 (KCl); and in the vein, 10(-5) mol litre-1 (U46619) and 10(-4) mol litre-1 (KCl, caffeine). We conclude that propofol at lower concentrations appeared to primarily attenuate contraction involving release of cellularly sequestered calcium. At higher concentrations (> 10(-4.5) mol litre-1), propofol appeared to affect contraction involving extracellular or intracellular calcium fluxes similarly.},
  author       = {Wallerstedt, S M and Bodelsson, Mikael},
  issn         = {1471-6771},
  language     = {eng},
  number       = {3},
  pages        = {296--300},
  publisher    = {Macmillan},
  series       = {British Journal of Anaesthesia},
  title        = {Effect of propofol on isolated human omental arteries and veins},
  volume       = {78},
  year         = {1997},
}