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Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations

Olsson, Martin L LU ; Guerreiro, Joao F; Zago, Marco A and Chester, Alan LU (1997) In Biochemical and Biophysical Research Communications 234(3). p.779-782
Abstract
The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians. Several previously undescribed O alleles were found, predominantly in the Black group, in which about a third of the samples did not conform to previously known O allele structures. It has been well documented for the first time that some new alleles can arise from crossing-over events between known alleles in the ABO system. This was made possible by both restriction endonuclease analysis and direct sequencing of exons 3-7 in the ABO gene. The anticipated relatively high frequency of some of these new alleles in certain populations, necessitates great care when interpreting... (More)
The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians. Several previously undescribed O alleles were found, predominantly in the Black group, in which about a third of the samples did not conform to previously known O allele structures. It has been well documented for the first time that some new alleles can arise from crossing-over events between known alleles in the ABO system. This was made possible by both restriction endonuclease analysis and direct sequencing of exons 3-7 in the ABO gene. The anticipated relatively high frequency of some of these new alleles in certain populations, necessitates great care when interpreting results from existing genotype screening methods. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
234
issue
3
pages
779 - 782
publisher
Elsevier
external identifiers
  • pmid:9175793
  • scopus:0031589992
ISSN
1090-2104
DOI
10.1006/bbrc.1997.6713
language
English
LU publication?
yes
id
2eb03155-f790-45da-8936-8ef325ba2cdc (old id 1111657)
date added to LUP
2008-07-18 09:50:41
date last changed
2017-01-01 07:20:00
@article{2eb03155-f790-45da-8936-8ef325ba2cdc,
  abstract     = {The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians. Several previously undescribed O alleles were found, predominantly in the Black group, in which about a third of the samples did not conform to previously known O allele structures. It has been well documented for the first time that some new alleles can arise from crossing-over events between known alleles in the ABO system. This was made possible by both restriction endonuclease analysis and direct sequencing of exons 3-7 in the ABO gene. The anticipated relatively high frequency of some of these new alleles in certain populations, necessitates great care when interpreting results from existing genotype screening methods.},
  author       = {Olsson, Martin L and Guerreiro, Joao F and Zago, Marco A and Chester, Alan},
  issn         = {1090-2104},
  language     = {eng},
  number       = {3},
  pages        = {779--782},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations},
  url          = {http://dx.doi.org/10.1006/bbrc.1997.6713},
  volume       = {234},
  year         = {1997},
}