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Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina

Agardh, Carl-David LU ; Agardh, Elisabet LU ; Zhang, Hui and Östenson, Claes-Göran (1997) In Journal of Diabetes and its Complications 11(3). p.158-162
Abstract
The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/-... (More)
The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/- 0.1; p < 0.01, and 2.6 +/- 0.2 versus 1.9 +/- 0.1; p < 0.001, respectively). Furthermore, in 24 to 30-months-old GK rats, the endothelial/pericyte ratio was higher than in 8 month old GK rats (p < 0.05). Thus, the GK rat appears to be a suitable model for experimental studies of chronic complications, including diabetic retinopathy, in NIDDM. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Diabetes and its Complications
volume
11
issue
3
pages
158 - 162
publisher
Elsevier
external identifiers
  • pmid:9174896
  • scopus:0031006055
ISSN
1873-460X
DOI
10.1016/S1056-8727(96)00049-9
language
English
LU publication?
yes
id
a624509e-9d10-4501-b0a4-f644a9a49a55 (old id 1111705)
date added to LUP
2008-07-18 11:06:34
date last changed
2017-01-01 07:24:27
@article{a624509e-9d10-4501-b0a4-f644a9a49a55,
  abstract     = {The Goto-Kakizaki (GK) rat represents a model of hereditary non-insulin-dependent diabetes mellitus (NIDDM), characterized by nonobesity, mild hyperglycemia from early life, impaired glucose tolerance test results, and a markedly defective insulin response to glucose. The rats develop signs of both nephropathy and neuropathy, but, to our knowledge, retinal changes have not been reported so far in this model of NIDDM. Hence, the aim of the present study was to assess whether morphological vascular changes could be demonstrated in retinal vessel preparations of GK rats. The endothelial/pericyte ratio was found to be higher in GK rats aged 8 months as well as after 24-30 months compared to their matched controls (2.3 +/- 0.2 versus 2.0 +/- 0.1; p &lt; 0.01, and 2.6 +/- 0.2 versus 1.9 +/- 0.1; p &lt; 0.001, respectively). Furthermore, in 24 to 30-months-old GK rats, the endothelial/pericyte ratio was higher than in 8 month old GK rats (p &lt; 0.05). Thus, the GK rat appears to be a suitable model for experimental studies of chronic complications, including diabetic retinopathy, in NIDDM.},
  author       = {Agardh, Carl-David and Agardh, Elisabet and Zhang, Hui and Östenson, Claes-Göran},
  issn         = {1873-460X},
  language     = {eng},
  number       = {3},
  pages        = {158--162},
  publisher    = {Elsevier},
  series       = {Journal of Diabetes and its Complications},
  title        = {Altered endothelial/pericyte ratio in Goto-Kakizaki rat retina},
  url          = {http://dx.doi.org/10.1016/S1056-8727(96)00049-9},
  volume       = {11},
  year         = {1997},
}