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Diagnostic efficacy of MnDPDP in MR imaging of the liver. A phase III multicentre study

Wang, C; Ahlstrom, H; Ekholm, S; Fagertun, H; Hellstrom, M; Hemmingsson, A; Holtås, Stig LU ; Isberg, B; Jonnson, E and Lonnemark-Magnusson, M, et al. (1997) In Acta Radiologica 38(4). p.643-649
Abstract
PURPOSE: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. MATERIAL AND METHODS: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20-60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related... (More)
PURPOSE: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. MATERIAL AND METHODS: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20-60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. RESULTS: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. CONCLUSION: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions. (Less)
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published
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Acta Radiologica
volume
38
issue
4
pages
643 - 649
publisher
John Wiley & Sons
external identifiers
  • pmid:9245958
  • scopus:0031179878
ISSN
1600-0455
language
English
LU publication?
yes
id
379930b7-1eec-4b53-96b7-b3f9c892231b (old id 1111858)
date added to LUP
2008-07-18 14:30:22
date last changed
2017-01-01 06:57:11
@article{379930b7-1eec-4b53-96b7-b3f9c892231b,
  abstract     = {PURPOSE: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. MATERIAL AND METHODS: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20-60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. RESULTS: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. CONCLUSION: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions.},
  author       = {Wang, C and Ahlstrom, H and Ekholm, S and Fagertun, H and Hellstrom, M and Hemmingsson, A and Holtås, Stig and Isberg, B and Jonnson, E and Lonnemark-Magnusson, M and McGill, S and Wallengren, N O and Westman, L},
  issn         = {1600-0455},
  language     = {eng},
  number       = {4},
  pages        = {643--649},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Diagnostic efficacy of MnDPDP in MR imaging of the liver. A phase III multicentre study},
  volume       = {38},
  year         = {1997},
}