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Time-dependency in brain lesion enhancement with gadodiamide injection

Åkeson, Per LU ; Nordström, Carl-Henrik LU and Holtås, Stig LU (1997) In Acta Radiologica 38(1). p.19-24
Abstract
PURPOSE: To determine the effective time window for MR imaging of tumors with blood-brain barrier (BBB) damage after injection of Gd-containing contrast media. MATERIAL AND METHODS: Eleven patients with 15 brain lesions (metastasis, glioma, abscess) were studied with a T1-weighted spin-echo sequence repeated over periods of up to 43 min after contrast injection. A quotient was calculated between the signals in the lesion and in the gray matter, and plotted against time. RESULTS: All lesions reached 70% of the maximum RATIO within 3.5 min. After 25 min 12 out of 15 lesions showed persistent enhancement within 15% of the maximal RATIO. CONCLUSION: The peak enhancement of BBB damage occurs around 3.5 min after injection. The effect does not... (More)
PURPOSE: To determine the effective time window for MR imaging of tumors with blood-brain barrier (BBB) damage after injection of Gd-containing contrast media. MATERIAL AND METHODS: Eleven patients with 15 brain lesions (metastasis, glioma, abscess) were studied with a T1-weighted spin-echo sequence repeated over periods of up to 43 min after contrast injection. A quotient was calculated between the signals in the lesion and in the gray matter, and plotted against time. RESULTS: All lesions reached 70% of the maximum RATIO within 3.5 min. After 25 min 12 out of 15 lesions showed persistent enhancement within 15% of the maximal RATIO. CONCLUSION: The peak enhancement of BBB damage occurs around 3.5 min after injection. The effect does not change during the next 25 min. Scanning should not be started until 2-5 min after injection of the contrast medium, and there is no advantage in waiting longer as no major increase (or decline) of contrast can be expected. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica
volume
38
issue
1
pages
19 - 24
publisher
John Wiley & Sons
external identifiers
  • pmid:9059396
  • scopus:0030639998
ISSN
1600-0455
language
English
LU publication?
yes
id
dbf546bc-ff33-4ecd-9e7f-9c9874ef75bc (old id 1111873)
date added to LUP
2008-07-18 14:40:29
date last changed
2017-10-01 04:51:11
@article{dbf546bc-ff33-4ecd-9e7f-9c9874ef75bc,
  abstract     = {PURPOSE: To determine the effective time window for MR imaging of tumors with blood-brain barrier (BBB) damage after injection of Gd-containing contrast media. MATERIAL AND METHODS: Eleven patients with 15 brain lesions (metastasis, glioma, abscess) were studied with a T1-weighted spin-echo sequence repeated over periods of up to 43 min after contrast injection. A quotient was calculated between the signals in the lesion and in the gray matter, and plotted against time. RESULTS: All lesions reached 70% of the maximum RATIO within 3.5 min. After 25 min 12 out of 15 lesions showed persistent enhancement within 15% of the maximal RATIO. CONCLUSION: The peak enhancement of BBB damage occurs around 3.5 min after injection. The effect does not change during the next 25 min. Scanning should not be started until 2-5 min after injection of the contrast medium, and there is no advantage in waiting longer as no major increase (or decline) of contrast can be expected.},
  author       = {Åkeson, Per and Nordström, Carl-Henrik and Holtås, Stig},
  issn         = {1600-0455},
  language     = {eng},
  number       = {1},
  pages        = {19--24},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Time-dependency in brain lesion enhancement with gadodiamide injection},
  volume       = {38},
  year         = {1997},
}