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The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Rosengren, Evald LU ; Åman, Pierre; Thelin, Sofia; Hansson, Christer LU ; Ahlfors, Stefan LU ; Björk, Peter LU ; Jacobsson, Lars and Rorsman, Hans LU (1997) In FEBS Letters 417(1). p.85-88
Abstract
A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Dopachrome tautomerase, Cytokine
in
FEBS Letters
volume
417
issue
1
pages
85 - 88
publisher
Wiley-Blackwell
external identifiers
  • pmid:9395080
  • scopus:0343580469
ISSN
1873-3468
DOI
10.1016/S0014-5793(97)01261-1
language
English
LU publication?
yes
id
51fc7f63-7860-4422-845b-554d65d03607 (old id 1112115)
date added to LUP
2008-07-21 12:55:05
date last changed
2017-11-05 04:25:45
@article{51fc7f63-7860-4422-845b-554d65d03607,
  abstract     = {A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.},
  author       = {Rosengren, Evald and Åman, Pierre and Thelin, Sofia and Hansson, Christer and Ahlfors, Stefan and Björk, Peter and Jacobsson, Lars and Rorsman, Hans},
  issn         = {1873-3468},
  keyword      = {Macrophage migration inhibitory factor,Phenylpyruvate tautomerase,Dopachrome tautomerase,Cytokine},
  language     = {eng},
  number       = {1},
  pages        = {85--88},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase},
  url          = {http://dx.doi.org/10.1016/S0014-5793(97)01261-1},
  volume       = {417},
  year         = {1997},
}