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Disturbances of autonomic nervous function in primary Sjogren's syndrome

Mandl, Thomas LU ; Jacobsson, L ; Lilja, B ; Sundkvist, Göran LU and Manthorpe, Rolf LU (1997) In Scandinavian Journal of Rheumatology 26(5). p.401-406
Abstract
Autonomic nervous function was evaluated by deep breathing [expiration/inspiration (E/I) ratio] and tilt table tests [acceleration (AI) and brake indices (BI)] in 19 patients with primary Sjogren's syndrome (pSS) and in 56 age matched controls. The E/I-ratio and systolic blood pressure (at rest, 1, and 8 min after tilt) were found to be significantly reduced (p < 0.001, p < 0.05, p < 0.01, p < 0.01 respectively) in patients with pSS whereas neither AI, BI nor diastolic blood pressure did differ significantly between patients and controls (NS). The van Bijsterveld's score correlated negatively with the AI (r = -0.77, p< 0.001) as well as the BI (r = -0.60, p < 0.01). No correlations were found between the 3 autonomic nerve... (More)
Autonomic nervous function was evaluated by deep breathing [expiration/inspiration (E/I) ratio] and tilt table tests [acceleration (AI) and brake indices (BI)] in 19 patients with primary Sjogren's syndrome (pSS) and in 56 age matched controls. The E/I-ratio and systolic blood pressure (at rest, 1, and 8 min after tilt) were found to be significantly reduced (p < 0.001, p < 0.05, p < 0.01, p < 0.01 respectively) in patients with pSS whereas neither AI, BI nor diastolic blood pressure did differ significantly between patients and controls (NS). The van Bijsterveld's score correlated negatively with the AI (r = -0.77, p< 0.001) as well as the BI (r = -0.60, p < 0.01). No correlations were found between the 3 autonomic nerve function parameters (E/I-ratio, AI, BI) and unstimulated whole sialometry or salivary gland scintigraphy. We conclude that autonomic disturbances, mainly affecting the parasympathetic nerves are associated with pSS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sjögren syndrome, Primary, Exploration, Diseases of the autonomic nervous system, Correlation analysis, Symptomatology, Human, Eye disease, Stomatology, Systemic disease, Immunopathology, Autoimmune disease, Nervous system diseases
in
Scandinavian Journal of Rheumatology
volume
26
issue
5
pages
401 - 406
publisher
Taylor & Francis
external identifiers
  • pmid:9385358
  • scopus:0038901640
ISSN
1502-7732
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Diabetes Epidemiology and Neuropathy (013241560), Department of Rheumatology (013036000)
id
7b0277e5-eda8-48f3-bf2c-c8fe8ff8dab3 (old id 1112123)
date added to LUP
2016-04-01 12:04:10
date last changed
2020-01-12 09:09:12
@article{7b0277e5-eda8-48f3-bf2c-c8fe8ff8dab3,
  abstract     = {Autonomic nervous function was evaluated by deep breathing [expiration/inspiration (E/I) ratio] and tilt table tests [acceleration (AI) and brake indices (BI)] in 19 patients with primary Sjogren's syndrome (pSS) and in 56 age matched controls. The E/I-ratio and systolic blood pressure (at rest, 1, and 8 min after tilt) were found to be significantly reduced (p &lt; 0.001, p &lt; 0.05, p &lt; 0.01, p &lt; 0.01 respectively) in patients with pSS whereas neither AI, BI nor diastolic blood pressure did differ significantly between patients and controls (NS). The van Bijsterveld's score correlated negatively with the AI (r = -0.77, p&lt; 0.001) as well as the BI (r = -0.60, p &lt; 0.01). No correlations were found between the 3 autonomic nerve function parameters (E/I-ratio, AI, BI) and unstimulated whole sialometry or salivary gland scintigraphy. We conclude that autonomic disturbances, mainly affecting the parasympathetic nerves are associated with pSS.},
  author       = {Mandl, Thomas and Jacobsson, L and Lilja, B and Sundkvist, Göran and Manthorpe, Rolf},
  issn         = {1502-7732},
  language     = {eng},
  number       = {5},
  pages        = {401--406},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Rheumatology},
  title        = {Disturbances of autonomic nervous function in primary Sjogren's syndrome},
  volume       = {26},
  year         = {1997},
}