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Early attachment of leucocytes, platelets and fibrinogen in endothelial cell-seeded Dacron venous conduits

Jensen, N; Lindblad, Bengt LU ; Ljungberg, J; Leide, S and Bergqvist, D (1997) In British Journal of Surgery 84(1). p.52-57
Abstract
BACKGROUND: There is a need for prosthetic venous conduits in surgery for trauma, cancer and thrombotic disease. Such conduits in use today have a low patency rate, leaving room for much improvement. METHODS: This experimental study investigated the dynamics of the early attachment of radiolabelled platelets, leucocytes and fibrinogen to endothelial cell-seeded Dacron venous conduits in sheep. Grafts were placed as jugular vein interposition grafts, seeded on one side, not seeded on the other, and followed for 4 h. RESULTS: No difference could be demonstrated between the two graft types. Platelets showed an increasing attachment during the whole period, leucocytes an immediate attachment followed by an undulating pattern, and fibrinogen an... (More)
BACKGROUND: There is a need for prosthetic venous conduits in surgery for trauma, cancer and thrombotic disease. Such conduits in use today have a low patency rate, leaving room for much improvement. METHODS: This experimental study investigated the dynamics of the early attachment of radiolabelled platelets, leucocytes and fibrinogen to endothelial cell-seeded Dacron venous conduits in sheep. Grafts were placed as jugular vein interposition grafts, seeded on one side, not seeded on the other, and followed for 4 h. RESULTS: No difference could be demonstrated between the two graft types. Platelets showed an increasing attachment during the whole period, leucocytes an immediate attachment followed by an undulating pattern, and fibrinogen an immediate attachment with a tendency to decrease. Measurements on the vein itself showed a high attachment and, for platelets, an extremely high attachment when measured after the graft in the direction of flow. CONCLUSION: The seeding process did not seem to affect early thrombogenicity. The carefully dissected vein wall showed highly thrombogenic properties, in many ways as high as in the prosthetic graft. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
84
issue
1
pages
52 - 57
publisher
John Wiley & Sons
external identifiers
  • pmid:9043452
  • scopus:0031028039
ISSN
1365-2168
language
English
LU publication?
yes
id
609d2940-e606-4089-bf8c-1528857a05ee (old id 1112211)
alternative location
http://www.ingentaconnect.com/content/jws/bjs/1997/00000084/00000001/art02489
date added to LUP
2008-07-21 15:52:24
date last changed
2017-01-01 05:10:11
@article{609d2940-e606-4089-bf8c-1528857a05ee,
  abstract     = {BACKGROUND: There is a need for prosthetic venous conduits in surgery for trauma, cancer and thrombotic disease. Such conduits in use today have a low patency rate, leaving room for much improvement. METHODS: This experimental study investigated the dynamics of the early attachment of radiolabelled platelets, leucocytes and fibrinogen to endothelial cell-seeded Dacron venous conduits in sheep. Grafts were placed as jugular vein interposition grafts, seeded on one side, not seeded on the other, and followed for 4 h. RESULTS: No difference could be demonstrated between the two graft types. Platelets showed an increasing attachment during the whole period, leucocytes an immediate attachment followed by an undulating pattern, and fibrinogen an immediate attachment with a tendency to decrease. Measurements on the vein itself showed a high attachment and, for platelets, an extremely high attachment when measured after the graft in the direction of flow. CONCLUSION: The seeding process did not seem to affect early thrombogenicity. The carefully dissected vein wall showed highly thrombogenic properties, in many ways as high as in the prosthetic graft.},
  author       = {Jensen, N and Lindblad, Bengt and Ljungberg, J and Leide, S and Bergqvist, D},
  issn         = {1365-2168},
  language     = {eng},
  number       = {1},
  pages        = {52--57},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Early attachment of leucocytes, platelets and fibrinogen in endothelial cell-seeded Dacron venous conduits},
  volume       = {84},
  year         = {1997},
}