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Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency

Rydén Ahlgren, Åsa LU orcid ; Piitulainen, Eeva LU ; Sonesson, Björn LU and Länne, T (1997) In European Journal of Vascular and Endovascular Surgery 14(4). p.252-257
Abstract
Objectives:



To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.

Material and methods:



Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.

Results:



There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex... (More)
Objectives:



To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.

Material and methods:



Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.

Results:



There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).

Conclusions:



No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ultrasound, Abdominal aortic aneurysms, α1-antitrypsin deficiency, Distensibility
in
European Journal of Vascular and Endovascular Surgery
volume
14
issue
4
pages
252 - 257
publisher
Elsevier
external identifiers
  • pmid:9366788
  • scopus:0030831530
ISSN
1532-2165
DOI
10.1016/S1078-5884(97)80236-5
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Respiratory Medicine and Allergology (013230111), Clinical Physiology and Nuclear Medicine Unit (013242320)
id
51fd1165-6d04-4ede-9b00-1d68789ea88a (old id 1112219)
date added to LUP
2016-04-01 16:48:04
date last changed
2022-03-30 18:21:48
@article{51fd1165-6d04-4ede-9b00-1d68789ea88a,
  abstract     = {{Objectives:<br/><br>
<br/><br>
To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.<br/><br>
Material and methods:<br/><br>
<br/><br>
Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.<br/><br>
Results:<br/><br>
<br/><br>
There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).<br/><br>
Conclusions:<br/><br>
<br/><br>
No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.}},
  author       = {{Rydén Ahlgren, Åsa and Piitulainen, Eeva and Sonesson, Björn and Länne, T}},
  issn         = {{1532-2165}},
  keywords     = {{Ultrasound; Abdominal aortic aneurysms; α1-antitrypsin deficiency; Distensibility}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{252--257}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Vascular and Endovascular Surgery}},
  title        = {{Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency}},
  url          = {{http://dx.doi.org/10.1016/S1078-5884(97)80236-5}},
  doi          = {{10.1016/S1078-5884(97)80236-5}},
  volume       = {{14}},
  year         = {{1997}},
}