Advanced

Bacterial virulence in urinary tract infection

Svanborg, Catharina LU and Godaly, Gabriela LU (1997) In Infectious Disease Clinics of North America 11(3). p.513-529
Abstract
Bacteriuria is associated with acute disease conditions of varying severity.48 and 62 Consequently, the definition of bacterial virulence for the urinary tract depends on the end-point chosen. Acute pyelonephritis is characterized by fever, flank pain, and general malaise. Laboratory findings include pyuria (leukocytes in the urine), elevated acute phase reactants in serum (C reactive protein [CRP], erythrocyte sedimentation rate [ESR]), elevated levels of cytokines in serum and urine, and later increased levels of antibacterial IgA antibodies in urine and serum.



Cystitis is characterized by dysuria, urgency, frequency of urination, and sometimes suprapubic pain. Acute cystitis should not be accompanied by acute phase... (More)
Bacteriuria is associated with acute disease conditions of varying severity.48 and 62 Consequently, the definition of bacterial virulence for the urinary tract depends on the end-point chosen. Acute pyelonephritis is characterized by fever, flank pain, and general malaise. Laboratory findings include pyuria (leukocytes in the urine), elevated acute phase reactants in serum (C reactive protein [CRP], erythrocyte sedimentation rate [ESR]), elevated levels of cytokines in serum and urine, and later increased levels of antibacterial IgA antibodies in urine and serum.



Cystitis is characterized by dysuria, urgency, frequency of urination, and sometimes suprapubic pain. Acute cystitis should not be accompanied by acute phase reactants or cytokines in the serum, however, there is pyuria, and IL-6 and IL-8 levels in urine may be elevated.



Asymptomatic bacteriuria (ABU) is commonly detected at screening because it is not accompanied by any of the symptoms seen for acute pyelonephritis and acute cystitis. The laboratory findings vary. The patients may have low level cytokine responses and leukocytes in urine, or they may have no host response to infection. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infectious Disease Clinics of North America
volume
11
issue
3
pages
513 - 529
publisher
Elsevier
external identifiers
  • pmid:9378921
  • scopus:0030879648
ISSN
0891-5520
DOI
10.1016/S0891-5520(05)70371-8
language
English
LU publication?
yes
id
2b28f17b-64b3-4c4f-970d-9e674342bb70 (old id 1112226)
date added to LUP
2008-07-21 16:10:20
date last changed
2017-07-09 04:21:21
@article{2b28f17b-64b3-4c4f-970d-9e674342bb70,
  abstract     = {Bacteriuria is associated with acute disease conditions of varying severity.48 and 62 Consequently, the definition of bacterial virulence for the urinary tract depends on the end-point chosen. Acute pyelonephritis is characterized by fever, flank pain, and general malaise. Laboratory findings include pyuria (leukocytes in the urine), elevated acute phase reactants in serum (C reactive protein [CRP], erythrocyte sedimentation rate [ESR]), elevated levels of cytokines in serum and urine, and later increased levels of antibacterial IgA antibodies in urine and serum.<br/><br>
<br/><br>
Cystitis is characterized by dysuria, urgency, frequency of urination, and sometimes suprapubic pain. Acute cystitis should not be accompanied by acute phase reactants or cytokines in the serum, however, there is pyuria, and IL-6 and IL-8 levels in urine may be elevated.<br/><br>
<br/><br>
Asymptomatic bacteriuria (ABU) is commonly detected at screening because it is not accompanied by any of the symptoms seen for acute pyelonephritis and acute cystitis. The laboratory findings vary. The patients may have low level cytokine responses and leukocytes in urine, or they may have no host response to infection.},
  author       = {Svanborg, Catharina and Godaly, Gabriela},
  issn         = {0891-5520},
  language     = {eng},
  number       = {3},
  pages        = {513--529},
  publisher    = {Elsevier},
  series       = {Infectious Disease Clinics of North America},
  title        = {Bacterial virulence in urinary tract infection},
  url          = {http://dx.doi.org/10.1016/S0891-5520(05)70371-8},
  volume       = {11},
  year         = {1997},
}