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The mechanical properties of elastic arteries in Ehlers-Danlos syndrome

Sonesson, Björn LU ; Hansen, Flemming and Länne, Toste (1997) In European Journal of Vascular and Endovascular Surgery 14(4). p.258-264
Abstract
OBJECTIVE: To study whether measurements of wall mechanics can be used as an indicator of disturbed vessel wall integrity and predictor of vessel fragility in Ehlers-Danlos Syndrome (EDS). METHODS: The wall mechanics of the abdominal aorta (AO) and common carotid artery (CCA) were estimated from the indices Ep (pressure strain elastic modulus) and stiffness (beta) in twelve individuals with EDS of different subtypes and compared with the results of a healthy reference population. Ep and beta were calculated from diameter and pulsatile diameter change determined non-invasively with the aid of an ultrasonic echo-tracking system and blood pressure obtained by the auscultatory method. RESULTS: Compared with normal individuals and their... (More)
OBJECTIVE: To study whether measurements of wall mechanics can be used as an indicator of disturbed vessel wall integrity and predictor of vessel fragility in Ehlers-Danlos Syndrome (EDS). METHODS: The wall mechanics of the abdominal aorta (AO) and common carotid artery (CCA) were estimated from the indices Ep (pressure strain elastic modulus) and stiffness (beta) in twelve individuals with EDS of different subtypes and compared with the results of a healthy reference population. Ep and beta were calculated from diameter and pulsatile diameter change determined non-invasively with the aid of an ultrasonic echo-tracking system and blood pressure obtained by the auscultatory method. RESULTS: Compared with normal individuals and their confidence intervals, subjects with EDS had unaltered diameter, Ep and beta in the AO, as well as in the CCA. Analysis of covariance (ANCOVA) also showed unaltered results. AO: diameter (males p = 0.66, females p = 0.27), Ep (males p = 0.81, females p = 0.27) and beta (males p = 0.95, females p = 0.12). CCA: diameter (males p = 0.36, females p = 0.46), Ep (males p = 0.93, females p = 0.48) and beta (males p = 0.86, females p = 0.47). CONCLUSIONS: This investigation could not demonstrate any alteration in wall mechanics as a sign of disturbed vessel wall integrity of elastic arteries in EDS. This might indicate that the structural defect in the arterial wall collagen, and thus the tendency to vessel fragility, cannot be revealed under normal physiological pressure conditions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ehlers-Danlos syndrome, Arterial distensibility, Wall mechanics, Compliance, Echo-tracking, Ultrasonography
in
European Journal of Vascular and Endovascular Surgery
volume
14
issue
4
pages
258 - 264
publisher
Elsevier
external identifiers
  • pmid:9366789
  • scopus:0030827565
ISSN
1532-2165
DOI
10.1016/S1078-5884(97)80237-7
language
English
LU publication?
yes
id
b15fc9cb-f96a-46b8-8e8f-09dfe63cc597 (old id 1112256)
date added to LUP
2008-07-21 16:38:40
date last changed
2017-10-22 04:35:00
@article{b15fc9cb-f96a-46b8-8e8f-09dfe63cc597,
  abstract     = {OBJECTIVE: To study whether measurements of wall mechanics can be used as an indicator of disturbed vessel wall integrity and predictor of vessel fragility in Ehlers-Danlos Syndrome (EDS). METHODS: The wall mechanics of the abdominal aorta (AO) and common carotid artery (CCA) were estimated from the indices Ep (pressure strain elastic modulus) and stiffness (beta) in twelve individuals with EDS of different subtypes and compared with the results of a healthy reference population. Ep and beta were calculated from diameter and pulsatile diameter change determined non-invasively with the aid of an ultrasonic echo-tracking system and blood pressure obtained by the auscultatory method. RESULTS: Compared with normal individuals and their confidence intervals, subjects with EDS had unaltered diameter, Ep and beta in the AO, as well as in the CCA. Analysis of covariance (ANCOVA) also showed unaltered results. AO: diameter (males p = 0.66, females p = 0.27), Ep (males p = 0.81, females p = 0.27) and beta (males p = 0.95, females p = 0.12). CCA: diameter (males p = 0.36, females p = 0.46), Ep (males p = 0.93, females p = 0.48) and beta (males p = 0.86, females p = 0.47). CONCLUSIONS: This investigation could not demonstrate any alteration in wall mechanics as a sign of disturbed vessel wall integrity of elastic arteries in EDS. This might indicate that the structural defect in the arterial wall collagen, and thus the tendency to vessel fragility, cannot be revealed under normal physiological pressure conditions.},
  author       = {Sonesson, Björn and Hansen, Flemming and Länne, Toste},
  issn         = {1532-2165},
  keyword      = {Ehlers-Danlos syndrome,Arterial distensibility,Wall mechanics,Compliance,Echo-tracking,Ultrasonography},
  language     = {eng},
  number       = {4},
  pages        = {258--264},
  publisher    = {Elsevier},
  series       = {European Journal of Vascular and Endovascular Surgery},
  title        = {The mechanical properties of elastic arteries in Ehlers-Danlos syndrome},
  url          = {http://dx.doi.org/10.1016/S1078-5884(97)80237-7},
  volume       = {14},
  year         = {1997},
}