The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants
(1997) In Acta Pædiatrica 86(5). p.539-544- Abstract
- OBJECTIVE: The objective of this study was to evaluate whether a regular formula for premature infants supplemented with nucleotides has any influence on plasma lipids and erythrocyte membrane fatty acids. METHODS: Preterm infants fed either human milk supplemented with human milk protein (HM, n = 14), nucleotide-supplemented preterm formula (NF, n = 13), or a regular preterm formula (F, n = 13) were included in the study. The NF was supplemented with 18.2 mg cytidine monophosphate/l (CMP), 7.0 mg uridine monophosphate/l (UMP), 6.4 mg adenosine monophosphate/l (AMP), 3.0 mg inosine monophosphate/l (IMP) and 3.0 mg guanosine monophosphate/l (GMP). RESULTS: There were significantly higher concentrations of triglycerides (TG) in infants fed... (More)
- OBJECTIVE: The objective of this study was to evaluate whether a regular formula for premature infants supplemented with nucleotides has any influence on plasma lipids and erythrocyte membrane fatty acids. METHODS: Preterm infants fed either human milk supplemented with human milk protein (HM, n = 14), nucleotide-supplemented preterm formula (NF, n = 13), or a regular preterm formula (F, n = 13) were included in the study. The NF was supplemented with 18.2 mg cytidine monophosphate/l (CMP), 7.0 mg uridine monophosphate/l (UMP), 6.4 mg adenosine monophosphate/l (AMP), 3.0 mg inosine monophosphate/l (IMP) and 3.0 mg guanosine monophosphate/l (GMP). RESULTS: There were significantly higher concentrations of triglycerides (TG) in infants fed NF compared to those fed F (191.42 +/- 79.58 vs 108.21 +/- 43.73, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma). Infants fed F had significantly lower concentrations of total cholesterol (94.34 +/- 11.71 vs 115.69 +/- 39.29, p < 0.01) and TG in plasma (108.21 +/- 43.73 vs 172.27 +/- 68.19, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma) when compared to HM-fed infants. There were no significant differences in any of the erythrocyte membrane fatty acids and total long-chain polyunsaturated fatty acids (LC-PUFA) between NF and F during the study period (6 weeks). Furthermore, total LC-PUFA and docosahexaenoic acid (DHA) concentrations in red blood cell were not significantly different when infants fed NF were compared to those fed HM. In contrast, however, infants fed F had significantly lower concentrations of total n-3 LC-PUFA (p < 0.01) and DHA (p < 0.01) than those found in HM-fed infants. CONCLUSIONS: These results do not suggest an effect of nucleotides on the red blood cell LC-PUFA profile in preterm infants. However, the nucleotides may increase the concentrations of triglycerides in plasma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112306
- author
- Axelsson, Irene LU ; Flodmark, Carl-Erik LU ; Räihä, Niels LU ; Tacconi, M ; Visentin, M ; Minoli, I ; Moro, G and Warm, A
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dietary nucleotides, erythrocyte membrane fatty acids, Plasma lipids, preterm infants
- in
- Acta Pædiatrica
- volume
- 86
- issue
- 5
- pages
- 539 - 544
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0031007333
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.1997.tb08927.x
- language
- English
- LU publication?
- yes
- id
- 4383082b-9684-4efa-a4ee-ff406bb6fdab (old id 1112306)
- date added to LUP
- 2016-04-01 16:48:22
- date last changed
- 2022-01-28 22:17:42
@article{4383082b-9684-4efa-a4ee-ff406bb6fdab, abstract = {{OBJECTIVE: The objective of this study was to evaluate whether a regular formula for premature infants supplemented with nucleotides has any influence on plasma lipids and erythrocyte membrane fatty acids. METHODS: Preterm infants fed either human milk supplemented with human milk protein (HM, n = 14), nucleotide-supplemented preterm formula (NF, n = 13), or a regular preterm formula (F, n = 13) were included in the study. The NF was supplemented with 18.2 mg cytidine monophosphate/l (CMP), 7.0 mg uridine monophosphate/l (UMP), 6.4 mg adenosine monophosphate/l (AMP), 3.0 mg inosine monophosphate/l (IMP) and 3.0 mg guanosine monophosphate/l (GMP). RESULTS: There were significantly higher concentrations of triglycerides (TG) in infants fed NF compared to those fed F (191.42 +/- 79.58 vs 108.21 +/- 43.73, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma). Infants fed F had significantly lower concentrations of total cholesterol (94.34 +/- 11.71 vs 115.69 +/- 39.29, p < 0.01) and TG in plasma (108.21 +/- 43.73 vs 172.27 +/- 68.19, p < 0.001, mean +/- SD lipid concentrations, mg/100 ml plasma) when compared to HM-fed infants. There were no significant differences in any of the erythrocyte membrane fatty acids and total long-chain polyunsaturated fatty acids (LC-PUFA) between NF and F during the study period (6 weeks). Furthermore, total LC-PUFA and docosahexaenoic acid (DHA) concentrations in red blood cell were not significantly different when infants fed NF were compared to those fed HM. In contrast, however, infants fed F had significantly lower concentrations of total n-3 LC-PUFA (p < 0.01) and DHA (p < 0.01) than those found in HM-fed infants. CONCLUSIONS: These results do not suggest an effect of nucleotides on the red blood cell LC-PUFA profile in preterm infants. However, the nucleotides may increase the concentrations of triglycerides in plasma.}}, author = {{Axelsson, Irene and Flodmark, Carl-Erik and Räihä, Niels and Tacconi, M and Visentin, M and Minoli, I and Moro, G and Warm, A}}, issn = {{1651-2227}}, keywords = {{Dietary nucleotides; erythrocyte membrane fatty acids; Plasma lipids; preterm infants}}, language = {{eng}}, number = {{5}}, pages = {{539--544}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Pædiatrica}}, title = {{The influence of dietary nucleotides on erythrocyte membrane fatty acids and plasma lipids in preterm infants}}, url = {{http://dx.doi.org/10.1111/j.1651-2227.1997.tb08927.x}}, doi = {{10.1111/j.1651-2227.1997.tb08927.x}}, volume = {{86}}, year = {{1997}}, }