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Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development

Persson, Carl LU and Erjefält, Jonas LU (1997) In Trends in Pharmacological Sciences 18(4). p.117-123
Abstract
Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefalt summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Pharmacological Sciences
volume
18
issue
4
pages
117 - 123
publisher
Elsevier
external identifiers
  • pmid:9149540
  • scopus:0342871975
ISSN
0165-6147
DOI
10.1016/S0165-6147(97)01042-0
language
English
LU publication?
yes
id
a00aad28-a785-44bf-ac51-f395e8928a34 (old id 1112513)
date added to LUP
2008-07-22 12:45:40
date last changed
2017-08-13 04:30:15
@article{a00aad28-a785-44bf-ac51-f395e8928a34,
  abstract     = {Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefalt summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.},
  author       = {Persson, Carl and Erjefält, Jonas},
  issn         = {0165-6147},
  language     = {eng},
  number       = {4},
  pages        = {117--123},
  publisher    = {Elsevier},
  series       = {Trends in Pharmacological Sciences},
  title        = {Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development},
  url          = {http://dx.doi.org/10.1016/S0165-6147(97)01042-0},
  volume       = {18},
  year         = {1997},
}