Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development
(1997) In Trends in Pharmacological Sciences 18(4). p.117-123- Abstract
- Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefalt summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112513
- author
- Persson, Carl LU and Erjefält, Jonas LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Pharmacological Sciences
- volume
- 18
- issue
- 4
- pages
- 117 - 123
- publisher
- Elsevier
- external identifiers
-
- pmid:9149540
- scopus:0342871975
- ISSN
- 0165-6147
- DOI
- 10.1016/S0165-6147(97)01042-0
- language
- English
- LU publication?
- yes
- id
- a00aad28-a785-44bf-ac51-f395e8928a34 (old id 1112513)
- date added to LUP
- 2016-04-01 17:03:36
- date last changed
- 2022-02-28 01:31:37
@article{a00aad28-a785-44bf-ac51-f395e8928a34, abstract = {{Release of cytotoxic granule proteins from activated eosinophil granules is considered to be a key pathogenic mechanism in eosinophilic diseases. Degenerated eosinophils and extracellular eosinophil granules have been repeatedly depicted. The present overview describes evidence that eosinophil lysis and distribution of free eosinophil granules (as opposed to 'classical degranulation') is an important mechanism by which eosinophils affect their surroundings. Here, Carl Persson and Jonas Erjefalt summarize how recent reports on the induction of eosinophil lysis in vivo provide a new paradigm for eosinophil activation and thus constitute a novel basis for pharmacological manipulations in eosinophilic diseases.}}, author = {{Persson, Carl and Erjefält, Jonas}}, issn = {{0165-6147}}, language = {{eng}}, number = {{4}}, pages = {{117--123}}, publisher = {{Elsevier}}, series = {{Trends in Pharmacological Sciences}}, title = {{Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development}}, url = {{http://dx.doi.org/10.1016/S0165-6147(97)01042-0}}, doi = {{10.1016/S0165-6147(97)01042-0}}, volume = {{18}}, year = {{1997}}, }