Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion

Andreasson, Patrik ; Johansson, Bertil LU ; Carlsson, Magnus ; Jarlsfelt, Ingvar ; Fioretos, Thoas LU ; Mitelman, Felix LU orcid and Höglund, Mattias LU (1997) In Genes, Chromosomes and Cancer 20(3). p.299-304
Abstract
A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
20
issue
3
pages
299 - 304
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:9365838
  • scopus:0030780203
ISSN
1045-2257
DOI
10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K
language
English
LU publication?
yes
id
0413314c-840e-4260-8f7f-d62a565b12d8 (old id 1112562)
date added to LUP
2016-04-01 12:01:04
date last changed
2022-04-21 01:09:06
@article{0413314c-840e-4260-8f7f-d62a565b12d8,
  abstract     = {{A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.}},
  author       = {{Andreasson, Patrik and Johansson, Bertil and Carlsson, Magnus and Jarlsfelt, Ingvar and Fioretos, Thoas and Mitelman, Felix and Höglund, Mattias}},
  issn         = {{1045-2257}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{299--304}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Genes, Chromosomes and Cancer}},
  title        = {{BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion}},
  url          = {{http://dx.doi.org/10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K}},
  doi          = {{10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K}},
  volume       = {{20}},
  year         = {{1997}},
}