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BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion

Andreasson, Patrik; Johansson, Bertil LU ; Carlsson, Magnus; Jarlsfelt, Ingvar; Fioretos, Thoas LU ; Mitelman, Felix LU and Höglund, Mattias LU (1997) In Genes, Chromosomes and Cancer 20(3). p.299-304
Abstract
A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
20
issue
3
pages
299 - 304
publisher
John Wiley & Sons
external identifiers
  • pmid:9365838
  • scopus:0030780203
ISSN
1045-2257
DOI
10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K
language
English
LU publication?
yes
id
0413314c-840e-4260-8f7f-d62a565b12d8 (old id 1112562)
date added to LUP
2008-07-17 08:47:57
date last changed
2017-01-01 04:45:30
@article{0413314c-840e-4260-8f7f-d62a565b12d8,
  abstract     = {A BCR/ABL-negative chronic myeloid leukemia (CML) with t(12;14) (p12;q11-13) as the sole chromosomal abnormality was investigated by fluorescence in situ hybridization (FISH), which disclosed a cryptic insertion of ETV6 (previously called TEL), located at 12p12, into ABL at chromosome band 9q34. ETV6/ABL fusion was confirmed by RT-PCR, revealing that the first five exons of ETV6 were fused in frame with ABL at exon 2. Wild-type ETV6 was expressed, in accordance with the FISH results showing no deletion of the second ETV6 allele. ETV6/ABL chimeric transcripts have previously been reported in acute leukemias, but never before in CML. The present case suggests that ETV6/ABL positivity may constitute a new genetic subgroup of BCR-negative CML.},
  author       = {Andreasson, Patrik and Johansson, Bertil and Carlsson, Magnus and Jarlsfelt, Ingvar and Fioretos, Thoas and Mitelman, Felix and Höglund, Mattias},
  issn         = {1045-2257},
  language     = {eng},
  number       = {3},
  pages        = {299--304},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion},
  url          = {http://dx.doi.org/10.1002/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K},
  volume       = {20},
  year         = {1997},
}