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HCV-RNA levels increase during pregnancy in women with chronic hepatitis C

Wejstal, R; Widell, Anders LU and Norkrans, G (1998) In Scandinavian Journal of Infectious Diseases 30(2). p.111-113
Abstract
Alanine aminotransferase (ALT) levels decline during pregnancy in women chronically infected with hepatitis C virus (HCV). In order to understand further the underlying mechanisms, we prospectively followed 10 chronically infected women before, during and after pregnancy. ALT levels were analysed together with quantification of serum HCV-RNA using the branched DNA technology. As anticipated, the ALT levels significantly declined late in pregnancy and increased again after delivery. HCV-RNA levels, conversely, significantly increased late in pregnancy and returned to baseline levels 1 y after delivery. These findings suggest the importance of immune mediated mechanisms in controlling the viral replication and contributing to the liver... (More)
Alanine aminotransferase (ALT) levels decline during pregnancy in women chronically infected with hepatitis C virus (HCV). In order to understand further the underlying mechanisms, we prospectively followed 10 chronically infected women before, during and after pregnancy. ALT levels were analysed together with quantification of serum HCV-RNA using the branched DNA technology. As anticipated, the ALT levels significantly declined late in pregnancy and increased again after delivery. HCV-RNA levels, conversely, significantly increased late in pregnancy and returned to baseline levels 1 y after delivery. These findings suggest the importance of immune mediated mechanisms in controlling the viral replication and contributing to the liver injury in chronic hepatitis C. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
30
issue
2
pages
111 - 113
publisher
Informa Healthcare
external identifiers
  • pmid:9730293
  • scopus:0031842905
ISSN
1651-1980
DOI
10.1080/003655498750003456
language
English
LU publication?
yes
id
f94777ad-9629-4aac-853b-123bd6eed101 (old id 1112742)
date added to LUP
2008-07-11 09:40:39
date last changed
2017-05-14 04:15:28
@article{f94777ad-9629-4aac-853b-123bd6eed101,
  abstract     = {Alanine aminotransferase (ALT) levels decline during pregnancy in women chronically infected with hepatitis C virus (HCV). In order to understand further the underlying mechanisms, we prospectively followed 10 chronically infected women before, during and after pregnancy. ALT levels were analysed together with quantification of serum HCV-RNA using the branched DNA technology. As anticipated, the ALT levels significantly declined late in pregnancy and increased again after delivery. HCV-RNA levels, conversely, significantly increased late in pregnancy and returned to baseline levels 1 y after delivery. These findings suggest the importance of immune mediated mechanisms in controlling the viral replication and contributing to the liver injury in chronic hepatitis C.},
  author       = {Wejstal, R and Widell, Anders and Norkrans, G},
  issn         = {1651-1980},
  language     = {eng},
  number       = {2},
  pages        = {111--113},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {HCV-RNA levels increase during pregnancy in women with chronic hepatitis C},
  url          = {http://dx.doi.org/10.1080/003655498750003456},
  volume       = {30},
  year         = {1998},
}