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GBV-C/HGV infection in hepatitis C virus-infected deferred Swedish blood donors

Shev, S; Björkman, Per LU ; Norkrans, G; Foberg, U; Fryden, A; Lindh, G; Lindholm, A; Weiland, O and Widell, Anders LU (1998) In Journal of Medical Virology 54(2). p.75-79
Abstract
Sera from 62 hepatitis C virus (HCV)-infected Swedish blood donors were tested by a nested polymerase chain reaction using primers targeting the 5'-noncoding region of the GB virus-C/hepatitis G (GBV-C/HGV) genome and an enzyme-linked immunosorbent assay that detects antibodies to the envelope protein E2 of GBV-C/HGV (anti-E2). Fourteen (22%) and 21 (34%) of the 62 blood donors were found to be GBV-C/HGV RNA and anti-E2 positive, respectively. None of the blood donors was positive for both GBV-C/HGV RNA and anti-E2. Thus, 35 of 62 (56%) HCV-infected donors had been exposed to GBV-C/HGV infection. At sequencing of the 14 GBV-C/HGV isolates, 12 were identified as subtype 2a and 2 as subtype 2b. One of 7 (14%) donors with mild liver disease... (More)
Sera from 62 hepatitis C virus (HCV)-infected Swedish blood donors were tested by a nested polymerase chain reaction using primers targeting the 5'-noncoding region of the GB virus-C/hepatitis G (GBV-C/HGV) genome and an enzyme-linked immunosorbent assay that detects antibodies to the envelope protein E2 of GBV-C/HGV (anti-E2). Fourteen (22%) and 21 (34%) of the 62 blood donors were found to be GBV-C/HGV RNA and anti-E2 positive, respectively. None of the blood donors was positive for both GBV-C/HGV RNA and anti-E2. Thus, 35 of 62 (56%) HCV-infected donors had been exposed to GBV-C/HGV infection. At sequencing of the 14 GBV-C/HGV isolates, 12 were identified as subtype 2a and 2 as subtype 2b. One of 7 (14%) donors with mild liver disease such as steatosis and nonspecific reactive hepatitis had been exposed to GBV-C/HGV vs. 34 of 55 (62%) with chronic hepatitis with or without cirrhosis (P = 0.04). All other differences in histology were small between HCV and dual HCV GBV-C/HGV-infected donors. In conclusion, more than half of HCV-infected Swedish blood donors in this study were positive for either GBV-C/HGV RNA or anti-E2. GBV-C/HGV viremia and seropositivity were mutually exclusive. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HGV, HCV, GBV-C, anti-E2, blood donors, chronic hepatitis
in
Journal of Medical Virology
volume
54
issue
2
pages
75 - 79
publisher
John Wiley & Sons
external identifiers
  • pmid:9496362
  • scopus:2642659396
ISSN
1096-9071
DOI
10.1002/(SICI)1096-9071(199802)54:2<75::AID-JMV1>3.0.CO;2-L
language
English
LU publication?
yes
id
b6c11551-511b-4adb-a3bc-a502ebab965e (old id 1112751)
date added to LUP
2008-07-11 09:49:10
date last changed
2017-01-01 04:33:32
@article{b6c11551-511b-4adb-a3bc-a502ebab965e,
  abstract     = {Sera from 62 hepatitis C virus (HCV)-infected Swedish blood donors were tested by a nested polymerase chain reaction using primers targeting the 5'-noncoding region of the GB virus-C/hepatitis G (GBV-C/HGV) genome and an enzyme-linked immunosorbent assay that detects antibodies to the envelope protein E2 of GBV-C/HGV (anti-E2). Fourteen (22%) and 21 (34%) of the 62 blood donors were found to be GBV-C/HGV RNA and anti-E2 positive, respectively. None of the blood donors was positive for both GBV-C/HGV RNA and anti-E2. Thus, 35 of 62 (56%) HCV-infected donors had been exposed to GBV-C/HGV infection. At sequencing of the 14 GBV-C/HGV isolates, 12 were identified as subtype 2a and 2 as subtype 2b. One of 7 (14%) donors with mild liver disease such as steatosis and nonspecific reactive hepatitis had been exposed to GBV-C/HGV vs. 34 of 55 (62%) with chronic hepatitis with or without cirrhosis (P = 0.04). All other differences in histology were small between HCV and dual HCV GBV-C/HGV-infected donors. In conclusion, more than half of HCV-infected Swedish blood donors in this study were positive for either GBV-C/HGV RNA or anti-E2. GBV-C/HGV viremia and seropositivity were mutually exclusive.},
  author       = {Shev, S and Björkman, Per and Norkrans, G and Foberg, U and Fryden, A and Lindh, G and Lindholm, A and Weiland, O and Widell, Anders},
  issn         = {1096-9071},
  keyword      = {HGV,HCV,GBV-C,anti-E2,blood donors,chronic hepatitis},
  language     = {eng},
  number       = {2},
  pages        = {75--79},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Medical Virology},
  title        = {GBV-C/HGV infection in hepatitis C virus-infected deferred Swedish blood donors},
  url          = {http://dx.doi.org/10.1002/(SICI)1096-9071(199802)54:2<75::AID-JMV1>3.0.CO;2-L},
  volume       = {54},
  year         = {1998},
}