Ultrasound enhanced thrombolysis in experimental retinal vein occlusion in the rabbit
Larsson, Jörgen LU ; Carlson, Jonas LU
and Olsson, Bertil
LU
(1998)
In British Journal of Ophthalmology
82(12).
p.1438-1440
- Abstract
- AIMS: To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound. METHODS: 53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours. RESULTS: In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21%... (More)
- AIMS: To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound. METHODS: 53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours. RESULTS: In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21% of the vessels were open. In the group that was treated with streptokinase (25,000 IU/kg) and ultrasound, 64% of the vessels were open. The difference between groups 2 and 3 is statistically significant (p = 0.011) CONCLUSION: Adding pulsed low energy ultrasound makes it possible to lower the dose of streptokinase while maintaining a good thrombolytic effect. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112812
- author
- Larsson, Jörgen
LU
; Carlson, Jonas
LU
and Olsson, Bertil
LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Ophthalmology
- volume
- 82
- issue
- 12
- pages
- 1438 - 1440
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:9930279
- scopus:0031733169
- ISSN
- 1468-2079
- language
- English
- LU publication?
- yes
- id
- d9ab34b5-486b-4610-bc07-69bc81b943b5 (old id 1112812)
- alternative location
- http://bjo.bmj.com/cgi/content/full/82/12/1438
- date added to LUP
- 2016-04-01 15:18:38
- date last changed
- 2022-01-28 04:43:12
@article{d9ab34b5-486b-4610-bc07-69bc81b943b5,
abstract = {{AIMS: To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound. METHODS: 53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours. RESULTS: In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21% of the vessels were open. In the group that was treated with streptokinase (25,000 IU/kg) and ultrasound, 64% of the vessels were open. The difference between groups 2 and 3 is statistically significant (p = 0.011) CONCLUSION: Adding pulsed low energy ultrasound makes it possible to lower the dose of streptokinase while maintaining a good thrombolytic effect.}},
author = {{Larsson, Jörgen and Carlson, Jonas and Olsson, Bertil}},
issn = {{1468-2079}},
language = {{eng}},
number = {{12}},
pages = {{1438--1440}},
publisher = {{BMJ Publishing Group}},
series = {{British Journal of Ophthalmology}},
title = {{Ultrasound enhanced thrombolysis in experimental retinal vein occlusion in the rabbit}},
url = {{http://bjo.bmj.com/cgi/content/full/82/12/1438}},
volume = {{82}},
year = {{1998}},
}