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Ultrasound enhanced thrombolysis in experimental retinal vein occlusion in the rabbit

Larsson, Jörgen LU ; Carlson, Jonas LU and Olsson, Bertil LU (1998) In British Journal of Ophthalmology 82(12). p.1438-1440
Abstract
AIMS: To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound. METHODS: 53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours. RESULTS: In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21%... (More)
AIMS: To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound. METHODS: 53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours. RESULTS: In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21% of the vessels were open. In the group that was treated with streptokinase (25,000 IU/kg) and ultrasound, 64% of the vessels were open. The difference between groups 2 and 3 is statistically significant (p = 0.011) CONCLUSION: Adding pulsed low energy ultrasound makes it possible to lower the dose of streptokinase while maintaining a good thrombolytic effect. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Ophthalmology
volume
82
issue
12
pages
1438 - 1440
publisher
BMJ Publishing Group
external identifiers
  • pmid:9930279
  • scopus:0031733169
ISSN
1468-2079
language
English
LU publication?
yes
id
d9ab34b5-486b-4610-bc07-69bc81b943b5 (old id 1112812)
alternative location
http://bjo.bmj.com/cgi/content/full/82/12/1438
date added to LUP
2008-07-11 11:30:33
date last changed
2017-01-01 06:37:16
@article{d9ab34b5-486b-4610-bc07-69bc81b943b5,
  abstract     = {AIMS: To investigate if it was possible to lower the dose of streptokinase and maintain an effective thrombolysis by adding pulsed low energy ultrasound. METHODS: 53 retinal veins in 27 rabbits were occluded by rose bengal enhanced laser treatment. Six rabbits were treated with streptokinase (50,000 IU/kg), 10 rabbits were treated with a low dose of streptokinase (25,000 IU/kg), and 11 rabbits were treated with a low dose of streptokinase (25,000 IU/kg) and pulsed ultrasound during 1 hour. Fluorescein angiography was performed immediately before the thrombolytic treatment and after 12 hours. RESULTS: In the group treated with streptokinase (50,000 IU/kg) all vessels were open. In the group that was given streptokinase (25,000 IU/kg), 21% of the vessels were open. In the group that was treated with streptokinase (25,000 IU/kg) and ultrasound, 64% of the vessels were open. The difference between groups 2 and 3 is statistically significant (p = 0.011) CONCLUSION: Adding pulsed low energy ultrasound makes it possible to lower the dose of streptokinase while maintaining a good thrombolytic effect.},
  author       = {Larsson, Jörgen and Carlson, Jonas and Olsson, Bertil},
  issn         = {1468-2079},
  language     = {eng},
  number       = {12},
  pages        = {1438--1440},
  publisher    = {BMJ Publishing Group},
  series       = {British Journal of Ophthalmology},
  title        = {Ultrasound enhanced thrombolysis in experimental retinal vein occlusion in the rabbit},
  volume       = {82},
  year         = {1998},
}