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Proliferative index obtained by DNA image cytometry. Does it add prognostic information in Auer IV breast cancer?

Baldetorp, Bo LU ; Fernö, Mårten LU ; Bendahl, Pär-Ola LU ; Fallenius, G; Idvall, Ingrid LU ; Åkerman, Måns LU and Killander, Dick LU (1998) In Analytical and Quantitative Cytology and Histology 20(2). p.144-152
Abstract
OBJECTIVE: To investigate whether the S + G2/M fraction (proliferative index) is a prognostic determinant in breast cancers classified as Auer IV. STUDY DESIGN: Prognostic evaluation of Auer IV DNA histograms with respect to the high versus low S + G2/M fraction, obtained by image cytometry on consecutive breast cancer imprint preparations. RESULTS: When studying recurrence-free survival (n = 136), the prognostic value of S + G2/M was found to vary with time: it was negligible before the median time to relapse (1.5 years) but thereafter statistically significant, in both univariate and multivariate analysis. The same pattern was found when overall survival was used as the end point; the effect was delayed to about the median time until... (More)
OBJECTIVE: To investigate whether the S + G2/M fraction (proliferative index) is a prognostic determinant in breast cancers classified as Auer IV. STUDY DESIGN: Prognostic evaluation of Auer IV DNA histograms with respect to the high versus low S + G2/M fraction, obtained by image cytometry on consecutive breast cancer imprint preparations. RESULTS: When studying recurrence-free survival (n = 136), the prognostic value of S + G2/M was found to vary with time: it was negligible before the median time to relapse (1.5 years) but thereafter statistically significant, in both univariate and multivariate analysis. The same pattern was found when overall survival was used as the end point; the effect was delayed to about the median time until death (three years). Tumors with a low S + G2/M fraction were smaller and more often estrogen receptor- and progesterone receptor-positive than those with a high S + G2/M fraction. CONCLUSION: According to ICM-DNA values corresponding to the S + G2/M region, patients with breast cancers classified as Auer IV can be divided into subgroups with different tumor characteristics and prognoses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Quantitative Cytology and Histology
volume
20
issue
2
pages
144 - 152
publisher
Science Printers
external identifiers
  • pmid:9569972
  • scopus:0031943357
ISSN
0884-6812
language
English
LU publication?
yes
id
350af0e3-75ac-4ca6-be2e-0bcbf3af238b (old id 1112854)
date added to LUP
2008-07-11 13:36:44
date last changed
2017-01-01 06:52:39
@article{350af0e3-75ac-4ca6-be2e-0bcbf3af238b,
  abstract     = {OBJECTIVE: To investigate whether the S + G2/M fraction (proliferative index) is a prognostic determinant in breast cancers classified as Auer IV. STUDY DESIGN: Prognostic evaluation of Auer IV DNA histograms with respect to the high versus low S + G2/M fraction, obtained by image cytometry on consecutive breast cancer imprint preparations. RESULTS: When studying recurrence-free survival (n = 136), the prognostic value of S + G2/M was found to vary with time: it was negligible before the median time to relapse (1.5 years) but thereafter statistically significant, in both univariate and multivariate analysis. The same pattern was found when overall survival was used as the end point; the effect was delayed to about the median time until death (three years). Tumors with a low S + G2/M fraction were smaller and more often estrogen receptor- and progesterone receptor-positive than those with a high S + G2/M fraction. CONCLUSION: According to ICM-DNA values corresponding to the S + G2/M region, patients with breast cancers classified as Auer IV can be divided into subgroups with different tumor characteristics and prognoses.},
  author       = {Baldetorp, Bo and Fernö, Mårten and Bendahl, Pär-Ola and Fallenius, G and Idvall, Ingrid and Åkerman, Måns and Killander, Dick},
  issn         = {0884-6812},
  language     = {eng},
  number       = {2},
  pages        = {144--152},
  publisher    = {Science Printers},
  series       = {Analytical and Quantitative Cytology and Histology},
  title        = {Proliferative index obtained by DNA image cytometry. Does it add prognostic information in Auer IV breast cancer?},
  volume       = {20},
  year         = {1998},
}