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Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging

Ilver, D; Arnqvist, A; Ogren, J; Frick, Inga-Maria LU ; Kersulyte, D; Incecik, E T; Berg, D E; Covacci, A; Engstrand, L and Boren, T (1998) In Science 279(5349). p.373-377
Abstract
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
279
issue
5349
pages
373 - 377
publisher
The American Association for the Advancement of Science
external identifiers
  • pmid:9430586
  • scopus:15444357984
ISSN
1095-9203
DOI
10.1126/science.279.5349.373
language
English
LU publication?
yes
id
13b0c457-51d5-4f7e-9bb8-f34e22dcaeec (old id 1113008)
date added to LUP
2008-07-14 10:37:49
date last changed
2017-11-19 04:14:04
@article{13b0c457-51d5-4f7e-9bb8-f34e22dcaeec,
  abstract     = {The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.},
  author       = {Ilver, D and Arnqvist, A and Ogren, J and Frick, Inga-Maria and Kersulyte, D and Incecik, E T and Berg, D E and Covacci, A and Engstrand, L and Boren, T},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5349},
  pages        = {373--377},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging},
  url          = {http://dx.doi.org/10.1126/science.279.5349.373},
  volume       = {279},
  year         = {1998},
}