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Efficacy of cumulative doses of salbutamol administered via Turbuhaler or Diskhaler in patients with reversible airway obstruction

Carlsson, L G; Arwestrom, E; Friberg, K; Kallen, A; Lunde, H and Löfdahl, Claes-Göran LU (1998) In Allergy 53(7). p.712-715
Abstract
The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler and Diskhaler. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double-blind, double-dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50, 100, 200, and 400 microg, were given on one study day at intervals of 30 min. On another study day, five doses of salbutamol Diskhaler, 200, 200, 400, 800, and 1600 microg, were given with the same interval. The treatment days were separated by a washout period of at least 24 h. The inhalation technique was standardized and supervised. Efficacy variables were recorded before and after each study dose. The primary efficacy variable was... (More)
The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler and Diskhaler. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double-blind, double-dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50, 100, 200, and 400 microg, were given on one study day at intervals of 30 min. On another study day, five doses of salbutamol Diskhaler, 200, 200, 400, 800, and 1600 microg, were given with the same interval. The treatment days were separated by a washout period of at least 24 h. The inhalation technique was standardized and supervised. Efficacy variables were recorded before and after each study dose. The primary efficacy variable was forced expiratory volume in 1 s (FEV1). When parallel and linear cumulative dose-response curves were statistically compared on a logarithmic scale, the dose potency of salbutamol Turbuhaler vs salbutamol Diskhaler was 1.99 (95% confidence interval 1.52-2.54). This study indicates that only half the dose of salbutamol is required via Turbuhaler as via Diskhaler for the same bronchodilating effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diskhaler®, efficacy, relative potency, salbutamol, Turbuhaler®
in
Allergy
volume
53
issue
7
pages
712 - 715
publisher
Wiley-Blackwell
external identifiers
  • pmid:9700042
  • scopus:0031822095
ISSN
1398-9995
DOI
10.1111/j.1398-9995.1998.tb03959.x
language
English
LU publication?
yes
id
be83cc1d-8d16-4b14-bf5f-c9bd9884fa99 (old id 1113422)
date added to LUP
2008-07-15 09:43:15
date last changed
2017-01-01 06:56:08
@article{be83cc1d-8d16-4b14-bf5f-c9bd9884fa99,
  abstract     = {The study aimed to estimate the relative dose potency of salbutamol inhaled via Turbuhaler and Diskhaler. The 24 adult patients participating had chronic reversible airway obstruction. The study was of a double-blind, double-dummy, crossover, randomized design. Five doses of salbutamol Turbuhaler, 50, 50, 100, 200, and 400 microg, were given on one study day at intervals of 30 min. On another study day, five doses of salbutamol Diskhaler, 200, 200, 400, 800, and 1600 microg, were given with the same interval. The treatment days were separated by a washout period of at least 24 h. The inhalation technique was standardized and supervised. Efficacy variables were recorded before and after each study dose. The primary efficacy variable was forced expiratory volume in 1 s (FEV1). When parallel and linear cumulative dose-response curves were statistically compared on a logarithmic scale, the dose potency of salbutamol Turbuhaler vs salbutamol Diskhaler was 1.99 (95% confidence interval 1.52-2.54). This study indicates that only half the dose of salbutamol is required via Turbuhaler as via Diskhaler for the same bronchodilating effect.},
  author       = {Carlsson, L G and Arwestrom, E and Friberg, K and Kallen, A and Lunde, H and Löfdahl, Claes-Göran},
  issn         = {1398-9995},
  keyword      = {Diskhaler®,efficacy,relative potency,salbutamol,Turbuhaler®},
  language     = {eng},
  number       = {7},
  pages        = {712--715},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {Efficacy of cumulative doses of salbutamol administered via Turbuhaler or Diskhaler in patients with reversible airway obstruction},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.1998.tb03959.x},
  volume       = {53},
  year         = {1998},
}