Advanced

Heterogeneity of the O alleles at the blood group ABO locus in Amerindians

Olsson, Martin L LU ; Santos, S E; Guerreiro, J F; Zago, M A and Chester, Alan LU (1998) In Vox Sanguinis 74(1). p.46-50
Abstract
BACKGROUND AND OBJECTIVES: Amerindians are blood group O, but the distribution of the various O alleles is unknown. Their ABO genotypes were compared with samples from other Brazilian ethnic groups. MATERIALS AND METHODS: Genomic DNA was examined by PCR-RFLP analysis, PCR-SSP and direct sequencing. RESULTS: An unusual allele distribution was found, with 91% of the O alleles being O1variant. Almost half of these alleles had an additional novel mutation (G542A), which was also detected in a few other Brazilian and European samples. The O alleles correlated completely with ABO-related haplotypes previously determined by Southern blot. CONCLUSION: The three Amerindian tribes represent a homogeneous (ABO blood group) population, except for the... (More)
BACKGROUND AND OBJECTIVES: Amerindians are blood group O, but the distribution of the various O alleles is unknown. Their ABO genotypes were compared with samples from other Brazilian ethnic groups. MATERIALS AND METHODS: Genomic DNA was examined by PCR-RFLP analysis, PCR-SSP and direct sequencing. RESULTS: An unusual allele distribution was found, with 91% of the O alleles being O1variant. Almost half of these alleles had an additional novel mutation (G542A), which was also detected in a few other Brazilian and European samples. The O alleles correlated completely with ABO-related haplotypes previously determined by Southern blot. CONCLUSION: The three Amerindian tribes represent a homogeneous (ABO blood group) population, except for the G542A mutation. The presence of this mutation in all other populations examined suggests that it originated before the migration of man into America. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vox Sanguinis
volume
74
issue
1
pages
46 - 50
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:9481861
  • scopus:0031973746
ISSN
1423-0410
DOI
10.1046/j.1423-0410.1998.7410046.x
language
English
LU publication?
yes
id
b645e9c8-4e0e-4457-bb33-3fb8edabfd11 (old id 1113699)
date added to LUP
2008-07-16 10:03:31
date last changed
2017-08-27 05:28:49
@article{b645e9c8-4e0e-4457-bb33-3fb8edabfd11,
  abstract     = {BACKGROUND AND OBJECTIVES: Amerindians are blood group O, but the distribution of the various O alleles is unknown. Their ABO genotypes were compared with samples from other Brazilian ethnic groups. MATERIALS AND METHODS: Genomic DNA was examined by PCR-RFLP analysis, PCR-SSP and direct sequencing. RESULTS: An unusual allele distribution was found, with 91% of the O alleles being O1variant. Almost half of these alleles had an additional novel mutation (G542A), which was also detected in a few other Brazilian and European samples. The O alleles correlated completely with ABO-related haplotypes previously determined by Southern blot. CONCLUSION: The three Amerindian tribes represent a homogeneous (ABO blood group) population, except for the G542A mutation. The presence of this mutation in all other populations examined suggests that it originated before the migration of man into America.},
  author       = {Olsson, Martin L and Santos, S E and Guerreiro, J F and Zago, M A and Chester, Alan},
  issn         = {1423-0410},
  language     = {eng},
  number       = {1},
  pages        = {46--50},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Vox Sanguinis},
  title        = {Heterogeneity of the O alleles at the blood group ABO locus in Amerindians},
  url          = {http://dx.doi.org/10.1046/j.1423-0410.1998.7410046.x},
  volume       = {74},
  year         = {1998},
}